Gastrointestinal Stromal Tumor (GIST) in Long-Standing Crohn’s Disease on Anti-TNF Therapy

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References

  1. 1.

    Corless CL, Barnett CM, Heinrich MC. Gastrointestinal stromal tumours: origin and molecular oncology. Nat Rev Cancer. 2011;11(12):865–78. https://doi.org/10.1038/nrc3143.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Katzka DA, Loftus EV, Camilleri M. Evolving molecular targets in the treatment of nonmalignant gastrointestinal diseases. Clin Pharmacol Ther. 2012;92(3):306–20. https://doi.org/10.1038/clpt.2012.77.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - a population-based study in western Sweden. Cancer. 2005;103(4):821–9. https://doi.org/10.1002/cncr.20862.

    Article  PubMed  Google Scholar 

  4. 4.

    Goettsch WG, Bos SD, Breekveldt-Postma N, Casparie M, Herings RMC, Hogendoorn PCW. Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study. Eur J Cancer. 2005;41(18):2868–72. https://doi.org/10.1016/j.ejca.2005.09.009.

    Article  PubMed  Google Scholar 

  5. 5.

    Ma GL, Murphy JD, Martinez ME, Sicklick JK. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomark Prev. 2015;24(1):298–302. https://doi.org/10.1158/1055-9965.EPI-14-1002.

    Article  Google Scholar 

  6. 6.

    Novelli M, Rossi S, Rodriguez-Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57(2):259–70. https://doi.org/10.1111/j.1365-2559.2010.03624.x.

    Article  PubMed  Google Scholar 

  7. 7.

    Pellino G, Marcellinaro R, Candilio G, de Fatico GS, Guadagno E, Campione S, et al. The experience of a referral centre and literature overview of GIST and carcinoid tumours in inflammatory bowel diseases. Int J Surg. 2016;28:S133–41. https://doi.org/10.1016/j.ijsu.2015.12.051.

    Article  PubMed  Google Scholar 

  8. 8.

    Emory TS, Sobin LH, Lukes L, Lee DH, O’Leary TJ. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol. 1999;23(1):82–7. https://doi.org/10.1097/00000478-199901000-00009.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23:70–83. https://doi.org/10.1053/j.semdp.2006.09.001.

    Article  PubMed  Google Scholar 

  10. 10.

    Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29(1):52–68. https://doi.org/10.1097/01.pas.0000146010.92933.de.

    Article  PubMed  Google Scholar 

  11. 11.

    Miettinen M, Makhlouf H, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol. 2006;30(4):477–89. https://doi.org/10.1097/00000478-200604000-00008.

    Article  PubMed  Google Scholar 

  12. 12.

    Demetri GD, Benjamin R, Blanke CD, et al. NCCN task force report: optimal management of patients with gastrointestinal stromal tumor (GIST)--expansion and update of NCCN Clinical Practice Guidelines. Vol 2 Suppl 1.; 2004.

  13. 13.

    Eorge D Emetri GD, Argaret Von Ehren MM, Harles B, Lanke CD, et al. The New Eng Land Jour Nal of Medicine Efficacy And Safety Of Imatinib Mesylate In Advanced Gastrointestinal Stromal Tumors A Bstract Background Constitutive Activation of KIT Receptor. Vol 347.; 2002. www.nejm.org.

  14. 14.

    Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006;368(9544):1329–38. https://doi.org/10.1016/S0140-6736(06)69446-4.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Körner M, Rehmann R, Reubi JC. GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn’s disease. Mol Cell Endocrinol. 2012;364(1–2):46–53. https://doi.org/10.1016/j.mce.2012.08.008.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Pfeffel F, Stiglbauer W, Depisch D, Oberhuber G, Raderer M, Scheithauer W. Coincidence of Crohn’s disease and a high-risk gastrointestinal stromal tumor of the terminal ileum. Digestion. 1999;60:363–6. https://doi.org/10.1159/000007684.

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Grieco A, Cavallaro A, Potenza AE, et al. Gastrointestinal stromal tumor (GIST) and ulcerative colitis. J Exp Clin Cancer Res. 2002.

  18. 18.

    Mijandrusic Sincic BM, Kovać D, Jašić M, Grbas H, Uravić M, Depolo A. Crohn’s disease and a gastrointestinal stromal tumor in an 81-year-old man - a rare coincidence. Zentralbl Chir. 2005;130:597–9. https://doi.org/10.1055/s-2005-918206.

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Kaiser AM, Kang JC, Tolazzi AR, Sherrod AE, Beart RW. Primary solitary extragastrointestinal stromal tumor of the greater omentum coexisting with ulcerative colitis. Dig Dis Sci. 2006;51(10):1850–2. https://doi.org/10.1007/s10620-006-9217-y.

    Article  PubMed  Google Scholar 

  20. 20.

    Ruffolo C, Massani M, Rossi S, Caratozzolo E, Antoniutti M, Bassi N. Adenocarcinoma and GIST in ulcerative colitis. Int J Color Dis. 2010;25(8):1027–8. https://doi.org/10.1007/s00384-010-0905-x.

    Article  Google Scholar 

  21. 21.

    Theodoropoulos GE, Linardoutsos D, Tsamis D, Stamopoulos P, Giannopoulos D, Zagouri F, et al. Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease. World J Gastroenterol. 2009;15(41):5224–7. https://doi.org/10.3748/wjg.15.5224.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Böcker U, Löhr JM, Marx A. Twenty-six-year-old female with assumed Crohn’s disease and a gastrointestinal stromal tumor: response. Inflamm Bowel Dis. 2009;15(4):489–90. https://doi.org/10.1002/ibd.20657.

    Article  PubMed  Google Scholar 

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Authors

Contributions

David Mendel M.D., case report drafting, literature review and discussion writing;

Taseen A. Syed M.B.B.S, M.D., case report revision, literature review, and discussion writing;

Lippman, H Robert M.D., pathology image selection;

Davis, Brian M.D., critical revision of the article and final approval of the manuscript.

All the authors reviewed the final manuscript before submission.

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Correspondence to Taseen Syed.

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Mendel, D., Syed, T., Lippman, H.R. et al. Gastrointestinal Stromal Tumor (GIST) in Long-Standing Crohn’s Disease on Anti-TNF Therapy. J Gastrointest Canc (2020). https://doi.org/10.1007/s12029-020-00442-8

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