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Resected High-Risk Rectal GIST Harboring NTRK1 Fusion: a Case Report and Review of the Literature

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References

  1. Joensuu H, Hohenberger P, Corless CL. Gastrointestinal stromal tumour. Lancet. 2013;382:973–83. https://doi.org/10.1016/S0140-6736(13)60106-3.

    Article  CAS  PubMed  Google Scholar 

  2. Corless CL, Barnett CM, Heinrich MC. Gastrointestinal stromal tumours: origin and molecular oncology. Nat Rev Cancer. 2011;11:865–78. https://doi.org/10.1038/nrc3143.

    Article  CAS  PubMed  Google Scholar 

  3. Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet. 2007;369:1731–41. https://doi.org/10.1016/S0140-6736(07)60780-6.

    Article  CAS  PubMed  Google Scholar 

  4. Heinrich MC, Corless CL, Blanke CD, Demetri GD, Joensuu H, Roberts PJ, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol. 2006;24:4764–74.

    Article  CAS  Google Scholar 

  5. Shi E, Chmielecki J, Tang CM, Wang K, Heinrich MC, Kang G, et al. FGFR1 and NTRK3 actionable alterations in "wild-type" gastrointestinal stromal tumors. J Transl Med. 2016;14:339.

    Article  Google Scholar 

  6. Boikos SA, Pappo AS, Killian JK, LaQuaglia MP, Weldon CB, George S, et al. Molecular subtypes of KIT/PDGFRA wild-type gastrointestinal stromal tumors: a report from the National Institutes of Health Gastrointestinal Stromal Tumor Clinic. JAMA Oncol. 2016;2:922–8. https://doi.org/10.1001/jamaoncol.2016.0256.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Brenca M, Rossi S, Polano M, Gasparotto D, Zanatta L, Racanelli D, et al. Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST. J Pathol. 2016;238:543–9. https://doi.org/10.1002/path.4677.

    Article  CAS  PubMed  Google Scholar 

  8. Casali PG, Abecassis N, Bauer S et al (2018) Gastrointestinal stromal tumours: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29 Suppl 4:iv68-iv78. https://doi.org/10.1093/annonc/mdy095.

  9. NCCN Clinical Practice Guidelines in Oncology. Soft tissue sarcoma. Version 6.2019 – February 10, 2020. https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf Accessed Apr 8, 2020.

  10. Hong DS, DuBois SG, Kummar S, et al. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials. Lancet Oncol. 2020;21:531–40. https://doi.org/10.1016/S1470-2045(19)30856-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mir O, Cropet C, Toulmonde M, Cesne AL, Molimard M, Bompas E, et al. Pazopanib plus best supportive care versus best supportive care alone in advanced gastrointestinal stromal tumours resistant to imatinib and sunitinib (PAZOGIST): a randomised, multicenter, open-label phase 2 trial. Lancet Oncol. 2016;17:632–41. https://doi.org/10.1016/S1470-2045(16)00075-9.

    Article  CAS  PubMed  Google Scholar 

  12. Falchook GS, Trent JC, Heinrich MC, et al. BRAF mutant gastrointestinal stromal tumor: first report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. Oncotarget. 2013;4:310–5. https://doi.org/10.18632/oncotarget.864.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Jessen WJ, Miller SJ, Jousma E, Wu J, Rizvi TA, Brundage ME, et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest. 2013;123:340–7. https://doi.org/10.1172/JCI60578.

    Article  CAS  PubMed  Google Scholar 

  14. Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, et al. Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci U S A. 2008;105:8387–92. https://doi.org/10.1073/pnas.0803383105.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Renata D’Alpino Peixoto.

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D’Alpino Peixoto, R., Medeiros, B.A. & Cronemberger, E.H. Resected High-Risk Rectal GIST Harboring NTRK1 Fusion: a Case Report and Review of the Literature. J Gastrointest Canc 52, 316–319 (2021). https://doi.org/10.1007/s12029-020-00423-x

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