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Treatment Patterns Among Patients with Metastatic and/or Unresectable Gastric Cancer in Brazil

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Abstract

Purpose

In Brazil, patients with gastric cancer have not been systematically followed-up and evaluated, thus data regarding patterns of care and outcomes are scarce or missing. The objective of this study was to evaluate patterns of care of advanced gastric cancer in standard practice in Brazil.

Methods

This was an observational, multicenter, retrospective study, which included patients with metastatic and/or unresectable gastric cancer (MGC) who underwent at least one line of treatment.

Results

We analyzed data on 155 patients diagnosed with MGC, most are men (57.4%), with mean age of 61.9 years at diagnosis, with 99 (63.9%) from the public healthcare system and 56 (36.1%) from the private setting. Platinum- and/or fluoropyrimidine-containing regimens prevailed as first-line therapy, while irinotecan was the most used regimen in the second and in the third lines. More than 40% of patients underwent only one line of systemic therapy, of which around 40% either died during the treatment or went on to best supportive care (BSC) only. The remaining patients received further treatment lines. A fifth of the patients in the study died within two months after discontinuation of the first-line treatment. Adverse events, use of concomitant medications, support procedures, outpatient visits, and hospitalizations were reported for most patients, especially in the first and second lines of treatment and during exclusive BSC.

Conclusions

Survival during or after the first-line chemotherapy remains poor among patients with MGC. Adverse events and health resource use were common in the first and second lines of treatment and in exclusive BSC. These results suggest that there is space for improvement in the treatment of MGC in Brazil.

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Acknowledgements

Some findings of this paper were presented at the 19th European ISPOR Congress 2016 as a poster presentation with partial results. This study was funded by the Eli Lilly and Company. The authors are grateful for the support of Carolina Santinho, Christiane Bueno, Eloisa de Sá Moreira, Gabriel Prolla, Luiz Fernando Andrade Feijó, Renata Eiras Martins, Estela Federal, and Mayara Piani and all site staff involved in the study.

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Authors and Affiliations

  1. Instituto COI de Educação e Pesquisa, Rio de Janeiro, Brazil

    Fernando Meton de Alencar Camara Vieira

  2. Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, Brazil

    Ana Paula Ornellas de Souza Victorino

  3. Centro de Estudos e Pesquisas de Hematologia e Oncologia/FM ABC, Santo André, Brazil

    Daniel de Iracema Gomes Cubero

  4. Fundação Amaral Carvalho, Jaú, Brazil

    Carlos Augusto de Mendonça Beato

  5. Evidências—Kantar Health, São Paulo, Brazil

    Eimy Minowa & Guilherme Silva Julian

  6. Lilly Research Centre, Eli Lilly and Company, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK

    Diego Novick

Authors
  1. Fernando Meton de Alencar Camara Vieira
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  2. Ana Paula Ornellas de Souza Victorino
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  3. Daniel de Iracema Gomes Cubero
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  7. Diego Novick
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Corresponding author

Correspondence to Diego Novick.

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Conflict of Interest

Diego Novick is an employee of Eli Lilly and Company Inc.; Eimy Minowa and Guilherme Silva Julian are employees of Kantar Health. The remaining authors declare that they have no conflicts of interest relevant to the manuscript submission.

Financial Support

This study was sponsored by Eli Lilly and Company.

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de Alencar Camara Vieira, F.M., de Souza Victorino, A.P.O., de Iracema Gomes Cubero, D. et al. Treatment Patterns Among Patients with Metastatic and/or Unresectable Gastric Cancer in Brazil. J Gastrointest Canc 50, 780–793 (2019). https://doi.org/10.1007/s12029-018-0145-9

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  • DOI: https://doi.org/10.1007/s12029-018-0145-9

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