A Rapidly Developing Diffuse Large B cell Lymphoma of the Stomach

  • Atsushi Goto
  • Jun Nishikawa
  • Shunsuke Ito
  • Eizaburou Hideura
  • Ryo Ogawa
  • Shinichi Hashimoto
  • Takeshi Okamoto
  • Isao Sakaida
Case Report


Diffuse large B cell lymphoma (DLBCL) is a common histologic type among gastric malignant lymphomas and is generally considered a high-grade lymphoma because of its high MIB-1 level. We describe our experience of observing DLBCL with extremely high MIB-1 by endoscopy and review the relevant literature.

Case Report

The patient was a 79-year-old man with anorexia. His past history includes chronic hepatitis C after achieving a sustained virological response by interferon treatment 10 years ago, and hepatitis B virus infection in the past. Blood tests showed the level of LDH and soluble interleukin-2 receptor to be slightly increased to 272 U/L and 594 U/mL respectively, but there were no other abnormalities. No neoplastic lesion was observed in his first esophagogastroduodenoscopy (EGD) (Fig.  1). Two months later, the patient again visited due to anorexia and weight loss of 5 kg. B symptoms such as fever and nocturnal sweating were not observed. Abdominal CT showed...


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyYamaguchi University Graduate School of MedicineUbeJapan
  2. 2.Department of Laboratory ScienceYamaguchi University Graduate School of MedicineUbeJapan

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