Liver Metastatic Melanoma: a Unique Case with Normal Alkaline Phosphatase and Melanuria

  • Bao X. Nguyen
  • Vincent S. Petros
  • Judith F. Aronson
  • Lindsay K. Sonstein
Case Report


Over the last decade, the incidence of melanoma has rapidly increased in the USA [1]. Liver involvement occurs frequently in metastatic melanoma, in approximately 10–20% of cases [2]. However, fulminant liver failure from metastatic malignant melanoma is rare, as only 11 cases are reported in the literature [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. In the cases which liver function tests were reported, all patients had elevated alkaline phosphatase (ALP). Furthermore, none of previous cases reported melanuria. We report a unique case of fulminant liver failure secondary to metastatic melanoma with normal ALP level and melanuria.

Case Presentation

A 41-year-old male presented to the internal medicine service for evaluation of malaise for 2 weeks, associated with 1 week of subjective fever and dark urine. His past medical history was significant for primary hypogonadism, for which he received weekly testosterone injections. Family history was positive for an unknown leukemia...


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from patient’s medical power of attorney.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Bao X. Nguyen
    • 1
  • Vincent S. Petros
    • 1
  • Judith F. Aronson
    • 2
  • Lindsay K. Sonstein
    • 1
  1. 1.Department of Internal MedicineUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA

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