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Hutchinson PJ, Jalloh I, Helmy A, Carpenter KLH, Rostami E, Bellander B-M, et al. Consensus statement from the 2014 international microdialysis forum. Intensive Care Med. 2015;41:1517–28.
Slais K, Vorisek I, Zoremba N, Homola A, Dmytrenko L, Sykova E. Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus. Exp Neurol. 2008;209:145–54.
Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OAC, et al. Neurometabolism in human epilepsy. Epilepsia. 2008;49:31–41.
Thomas PM, Phillips JP, O’Connor WT. Hippocampal microdialysis during spontaneous intraoperative epileptiform activity. Acta Neurochir (Wien). 2004;146:143–51.
Meurs A, Clinckers R, Ebinger G, Michotte Y, Smolders I. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy Res. 2008;78:50–9.
Çavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, et al. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: microdialysis study of 79 patients at the yale epilepsy surgery program: glutamate, glutamine, and GABA in refractory epilepsy. Ann Neurol. 2016;80:35–45.
Ronne-Engström E, Hillered L, Flink R, Spännare B, Ungerstedt U, Carlson H. Intracerebral microdialysis of extracellular amino acids in the human epileptic focus. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 1992;12:873–6.
Ungerstedt U, Rostami E. Microdialysis in neurointensive care. Curr Pharm Des. 2004;10:2145–52.
Lonjon M, Risso JJ, Palmier B, Negrin J, Darbin O. Effects of hypothermic deep-anaesthesia on energy metabolism at brain and peripheral levels: a multi-probe microdialysis study in free-moving rat. Neurosci Lett. 2001;304:21–4.
Schiefecker AJ, Beer R, Steidl J, Sohm F, Griesmacher A, Brendel AK, et al. Refractory status epilepticus in a patient with short bowel syndrome—a microdialysis study. Seizure. 2013;22:236–9.
Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, et al. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;35:2830–6.
During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet Lond Engl. 1993;341:1607–10.
Vespa PM, McArthur D, O’Phelan K, Glenn T, Etchepare M, Kelly D, et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23:865–77.
Cornford EM, Nguyen EV, Landaw EM. Acute upregulation of blood-brain barrier glucose transporter activity in seizures. Am J Physiol Heart Circ Physiol. 2000;279:H1346–54.
Nehlig A, Rudolf G, Leroy C, Rigoulot M-A, Simpson IA, Vannucci SJ. Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain. Brain Res. 2006;1082:32–42.
Chapman AG, Meldrum BS, Siesiö BK. Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem. 1977;28:1025–35.
Bascuñana P, Brackhan M, Leiter I, Keller H, Jahreis I, Ross TL, et al. Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism. J Cereb Blood Flow Metab. 2018;0271678X1880988.
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Hurth, H., Schlak, D. & Ebner, F.H. Microdialysis Findings in a Patient with New Onset Refractory Non-convulsive Status Epilepticus. Neurocrit Care 32, 889–893 (2020). https://doi.org/10.1007/s12028-019-00848-8
- Status epilepticus
- Intensive care