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Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective

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Abstract

A number of neurologic disorders can cause cardiac dysfunction by involving the conductive system and contractile apparatus of the heart. This is especially prominent in the neurocritical care setting where the spectrum of cardiac dysfunction due to acute neurologic injury ranges from trivial and isolated electrocardiographic changes to malignant arrhythmias and sudden death (Table 1). The mechanism of these cardiac complications is complex and not fully understood. An understanding of the neuroanatomical structures and pathways is of immense importance to comprehend the underlying pathophysiology that culminates as cardiac damage and dysregulation. Once the process is initiated, it can complicate and adversely affect the outcome of primary neurologic conditions commonly seen in the neurocritical care setting. Not only are these cardiac disorders under-recognized, there is a paucity of data to formulate evidence-based guidelines regarding early detection, acute management, and preventive strategies. However, certain details of clinical features and their course combined with location of primary neurologic lesion on neuroimaging and data obtained from laboratory investigations can be of great value to develop a strategy to appropriately manage these patients and to prevent adverse outcome from these cardiac complications. In this review, we highlight the mechanisms of cardiac dysfunction due to catastrophic neurologic conditions or due to stress of critical illness. We also address various clinical syndromes of cardiac dysfunction that occur as a result of the neurologic illness and in turn may complicate the course of the primary neurologic condition.

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Acknowledgments

The authors would like to acknowledge Dr. Robert P Lisak, MD for his help in editing the manuscript and his thoughtful comments.

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  1. Department of Neurology, Division of Neurocritical care, Wayne State University School of Medicine, Detroit, MI, USA

    Mohammad S. Ibrahim, Bennson Samuel, Wazim Mohamed & Kushak Suchdev

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  1. Mohammad S. Ibrahim
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MI and KS were responsible for study conception, literature search, writing and editing the manuscript. BS and WM were involved in editing the manuscript.

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Ibrahim, M.S., Samuel, B., Mohamed, W. et al. Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective. Neurocrit Care 30, 508–521 (2019). https://doi.org/10.1007/s12028-018-0636-3

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