A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and 133Xe-SPECT
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There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and 133Xenon single photon emission computer tomography (133Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P ≤ 0.033) at 15 min, but not at 60 min (P ≥ 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with 133Xe-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.
KeywordsCerebral blood flow Ultrasound tagged near infrared spectroscopy 133Xenon single photon emission computer tomography Acetazolamide Monitoring
- 17.Racheli N, Ron A, Metzger Y, Breskin I, Enden G, Balberg M, Shechter R. Non-invasive blood flow measurements using ultrasound modulated diffused light. In: Oravesky AA, Wang LV, editors. SPIE Conference Proceedings 8223 (Photons Plus Ultrasound: Imaging and Sensing). 2012.Google Scholar
- 18.Ron A, Racheli N, Breskin I, Metzger Y, Silman Y, Kamar M, Nini A, Shechter R, Balberg M. Measuring tissue blood flow using ultrasound modulated diffused light. In: Oravesky AA, Wang LV, editors. SPIE Conference Proceedings 8223 (Photons Plus Ultrasound: Imaging and Sensing). 2012.Google Scholar
- 21.Pocock S. A practical approach. London: Wiley; 1983. p. 123–41.Google Scholar