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Factors Associated with Favorable Response to Hyperbaric Oxygen Therapy among Patients Presenting with Iatrogenic Cerebral Arterial Gas Embolism

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Abstract

Background

Iatrogenic cerebral arterial gas embolism (CAGE) is an uncommon but potentially a fatal condition. Hyperbaric oxygen (HBO2) therapy is the only definitive treatment for patients with CAGE presenting with acute neurologic deficits.

Methods

We reviewed medical records and neuroimaging of consecutive CAGE patients treated with HBO2 at a state referral hyperbaric facility over a 22-year period. We analyzed the effect of demographics, source of intra-arterial gas, signs and symptoms, results of imaging studies, time between event and HBO2 treatment, and response to HBO2 treatment in 36 consecutive patients. Favorable outcome was defined by complete resolution or improvement of CAGE signs and symptoms at 24 h after HBO2 treatment. Unfavorable outcome was defined by unchanged or worsened neurologic signs and symptoms or in hospital death.

Results

A total of 26 (72%) of the 36 patients had favorable outcome. Patients with favorable outcome were younger compared to those with unfavorable outcome (mean age [years, SD] 44.7 ± 17.8 vs. 58.1 ± 24.1, p = 0.08). Cardiopulmonary symptoms were significantly more common in CAGE related to venous source of gas compared to arterial source (p = 0.024) but did not influence the rate of favorable outcomes. Adjusted multivariate analysis demonstrated that time from event to HBO2 ≤6 h (positively) and the presence of infarct/edema on head computerized tomography (CT)/magnetic resonance imaging (MRI) before HBO2 (negatively) were independent predictors of favorable outcome at 24 h after HBO2 treatment [odds ratio (OR) 9.08 confidence interval (CI) (1.13–72.69), p = 0.0376, and (OR) 0.034 (CI) (0.002–0.58), p = 0.0200, respectively]. Two of the 36 patients were treated with thrombolytics because of acute focal deficits and suspected ischemia—one with intravenous and the second with intra-arterial thrombolysis. The latter patient developed fatal intracerebral hemorrhage.

Conclusions

A high proportion of CAGE patients treated with HBO2 had favorable outcomes. Time-to-HBO2 ≤6 h increased the odds of favorable outcome, whereas the presence of infarct/edema on CT/MRI scan before HBO2 reduced the odds of a favorable outcome. Timely diagnosis and differentiation from thrombo-embolic ischemic events appears to be an important determinant of successful HBO2 treatment.

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Authors and Affiliations

  1. Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, 12-100 PWB, 516 Delaware St. SE, Minneapolis, MN, 55455, USA

    Wondwossen G. Tekle, Saqib A. Chaudhry, Vikram Jadhav, Ameer E. Hassan, Gustavo J. Rodriguez & Adnan I. Qureshi

  2. Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA

    Wondwossen G. Tekle, Cheryl D. Adkinson, Saqib A. Chaudhry, Vikram Jadhav, Ameer E. Hassan, Gustavo J. Rodriguez & Adnan I. Qureshi

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  1. Wondwossen G. Tekle
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  2. Cheryl D. Adkinson
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  3. Saqib A. Chaudhry
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  4. Vikram Jadhav
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  7. Adnan I. Qureshi
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Correspondence to Wondwossen G. Tekle.

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Tekle, W.G., Adkinson, C.D., Chaudhry, S.A. et al. Factors Associated with Favorable Response to Hyperbaric Oxygen Therapy among Patients Presenting with Iatrogenic Cerebral Arterial Gas Embolism. Neurocrit Care 18, 228–233 (2013). https://doi.org/10.1007/s12028-012-9683-3

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