IL-10-producing regulatory B cells are present and functional in primary Sjögren patients

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Data availability

All data generated or analyzed during this study are included in this published article.

Change history



anti-nuclear antibodies


anti-sicca syndrome A


anti-sicca syndrome A


IL-10-producing B cells


IL-10 non-producing B cells


Brefeldin A


Eular Sjögren Syndrome Disease Activity Index


peripheral blood mononuclear cells


Phorbol 12-myristate 13-acetate


primary Sjögren syndrome


rheumatoid arthritis


rheumatoid factor


T helper 1

TNFα T cells:

TNFα-producing T cells


regulatory T cells


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We thank Sumaiya Hoque for English correction of the manuscript and Claire Rempenault for her help in writing the manuscript. We acknowledge the imaging facility MRI, member of the national infrastructure France-BioImaging, supported by the French National Research Agency (ANR-10-INBS-04, “Investments for the future”), and more especially, Myriam Boyer and Sarah Gailhac for the cell sorting.


We received the financial support of the GCS-MERRI Nimes Montpellier and the AFGS (Association Française des patients atteints de Gougerot Sjögren et syndromes secs).

Author information




J.Mi designed and performed the experiments; collected, analyzed, and interpreted the data; and prepared and wrote the manuscript. A.R designed and performed the experiments; collected, analyzed, and interpreted the data; and wrote the manuscript. A.N. designed, conducted patient enrolment into the study and performed the experiments, interpreted the data, and critically read the manuscript. GV critically read the manuscript and gave scientific advice. P.G, B.C, and J.Mo contributed to patient enrolment into the study and critically read the manuscript. C.D. obtained financial support, designed the experiments, conducted patient enrolment into the study, interpreted the data, and wrote the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Claire Daien.

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The authors declare that they have no conflict of interest.

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This study has been approved by the Medical Ethics Committee of Nimes hospital, France (CPP_2012-A00592-41).

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Not applicable.

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The original online version of this article was revised: The first name and last name of the authors in the published version of this article have been exchanged.

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Mielle, J., Nutz, A., Guillpain, P. et al. IL-10-producing regulatory B cells are present and functional in primary Sjögren patients. Immunol Res 69, 107–113 (2021).

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