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Immunologic Research

, Volume 66, Issue 3, pp 348–354 | Cite as

Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients

  • Julian Ramírez-Bello
  • Daniel Cadena-Sandoval
  • Jorge Flavio Mendoza-Rincón
  • Rosa Elda Barbosa-Cobos
  • Fausto Sánchez-Muñoz
  • Luis M Amezcua-Guerra
  • Mónica Sierra-Martínez
  • Silvia Jiménez-Morales
Original Article
  • 99 Downloads

Abstract

The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population. Our study included 442 patients with SLE and 495 controls. For genotyping, we used the TaqMan 5′ allele discrimination assay. The TNF -238G/A and -1031T/C polymorphisms were associated with SLE susceptibility (odds ratio (OR) 2.1, p = 0.0005 and OR 1.4, p = 0.003, respectively). Gender stratification showed a strong association between TNF -238G/A and SLE in women (OR 2.2, p = 0.00006), while TNF -1031T/C had an OR of 1.5 (p = 0.007). With regard to the TNF -376G/A polymorphism, this also showed association with SLE susceptibility (OR 1.95, p = 0.036) and LN (OR 3.5, p = 0.01). In conclusion, our study provides the first demonstration of association between the TNF -376G/A polymorphism and SLE and LN susceptibility. In addition, our study is the second documenting an association of TNF -1031T/C with SLE susceptibility. We also observed a strong association between TNF -238G/A and SLE susceptibility. The TNF 308G/A polymorphism was not associated with SLE or LN.

Keywords

Systemic lupus erythematosus Rheumatoid arthritis Tumor necrosis factor Susceptibility 

Notes

Funding information

This study was supported by a grant of the Consejo Nacional de Ciencia y Tecnología de México (CONACyT) (FOSISS: project no. 233107).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Julian Ramírez-Bello
    • 1
    • 2
  • Daniel Cadena-Sandoval
    • 1
    • 3
  • Jorge Flavio Mendoza-Rincón
    • 4
  • Rosa Elda Barbosa-Cobos
    • 5
  • Fausto Sánchez-Muñoz
    • 6
  • Luis M Amezcua-Guerra
    • 6
  • Mónica Sierra-Martínez
    • 7
  • Silvia Jiménez-Morales
    • 8
  1. 1.Unidad de Investigación en Investigación en Enfermedades Metabólicas y EndócrinasHospital Juárez de MéxicoMexico CityMexico
  2. 2.Instituto Politécnico NacionalMexico CityMexico
  3. 3.Programa de Doctorado de la Escuela Superior de MedicinaInstituto Politécnico NacionalMexico CityMexico
  4. 4.Laboratorio de Oncología Molecular, Unidad de Diferenciacón Celular y Cáncer, FES-ZaragozaUNAMMexico CityMexico
  5. 5.Servicio de ReumatologíaHospital Juárez de MéxicoMexico CityMexico
  6. 6.Departamento de InmunologíaInstituto Nacional de CardiologíaMexico CityMexico
  7. 7.Laboratorio de Diagnóstico Molecular y GenéticaHospital Juárez de MéxicoMexico CityMexico
  8. 8.Laboratorio de Genómica del CáncerInstituto Nacional de Medicina GenómicaMexico CityMexico

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