Immunologic Research

, Volume 65, Issue 1, pp 293–295 | Cite as

The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature

  • M. Infantino
  • F. Meacci
  • V. Grossi
  • M. Manfredi
  • F. Li Gobbi
  • P. Sarzi-Puttini
  • F. Atzeni
  • M. Benucci
Therapeutic Aspects in Autoimmunity

Abstract

Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.

Keywords

Anti-nuclear antibodies Anti-DFS70 antibodies Undifferentiated connective tissue disease 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • M. Infantino
    • 1
  • F. Meacci
    • 1
  • V. Grossi
    • 1
  • M. Manfredi
    • 1
  • F. Li Gobbi
    • 2
  • P. Sarzi-Puttini
    • 3
  • F. Atzeni
    • 4
  • M. Benucci
    • 2
  1. 1.Laboratory of Immunology and AllergologyS. Giovanni di Dio HospitalFlorenceItaly
  2. 2.Rheumatology UnitS. Giovanni di Dio HospitalFlorenceItaly
  3. 3.Rheumatology UnitL. Sacco University HospitalMilanItaly
  4. 4.IRCCS Orthopedic Institute of GaleazziMilanItaly

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