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Immunologic Research

, Volume 65, Issue 1, pp 186–192 | Cite as

Rituximab therapy for IgA-vasculitis with nephritis: a case series and review of the literature

  • Roberta Fenoglio
  • Carla Naretto
  • Bruno Basolo
  • Giacomo Quattrocchio
  • Michela Ferro
  • Paola Mesiano
  • Giulietta Beltrame
  • Dario Roccatello
Therapeutic Aspects in Autoimmunity

Abstract

Henoch–Schonlein purpura, also called IgA-vasculitis, is a systemic small vessels vasculitis with immunoglobulin A1-dominant immune deposits. The optimal treatment remains controversial. Because IgA-vasculitis is characterized by leukocyte infiltration of the blood vessel walls along with immunoglobulin A deposition, and because glucocorticosteroids inhibit inflammatory processes, early administration of glucocorticosteroids has been postulated to be effective, but this indication remains controversial. Immunosuppressive agents (azathioprine, cyclophosphamide, cyclosporine, mycophenolate) have been used in combination with glucocorticosteroids without definitive evidence of effectiveness. The efficacy of rituximab in adult IgA-vasculitis has been reported in few cases. We described a monocentric experience on the use of rituximab in adult IgA-vasculitis with biopsy-proven nephritis. The patients achieved a complete remission of nephritis and syndromic manifestations, and no patients experienced adverse reactions. These data have been compared with the limited literature nowadays available.

Keywords

IgA-vasculitis Henoch–Schonlein purpura nephritis Henoch–Schonlein treatment Rituximab B cell depletion therapy ANCA-associated vasculitis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest, nor any financial interest with regard to the present paper.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Roberta Fenoglio
    • 1
  • Carla Naretto
    • 1
  • Bruno Basolo
    • 1
  • Giacomo Quattrocchio
    • 1
  • Michela Ferro
    • 1
  • Paola Mesiano
    • 1
  • Giulietta Beltrame
    • 1
  • Dario Roccatello
    • 1
  1. 1.Nephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic DiseasesGiovanni Bosco Hospital and University of TurinTurinItaly

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