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Receptor signaling in immune cell development and function

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Abstract

Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.

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Acknowledgments

The research is supported by grants from the American Heart Association, the American Cancer Society, NIH (R01-AI079088, R01-AI076357, R21-AI079873), and the Food Allergy and Anaphylaxis Network to Xiao-Ping Zhong.

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  1. Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA

    Xiao-Ping Zhong, Jinwook Shin, Balachandra K. Gorentla, Tommy O’Brien, Sruti Srivatsan, Li Xu, Yong Chen, Danli Xie & Hongjie Pan

  2. Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Xiao-Ping Zhong, Tommy O’Brien & Sruti Srivatsan

  3. Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Box 2644, Durham, NC, 27710, USA

    Xiao-Ping Zhong

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Zhong, XP., Shin, J., Gorentla, B.K. et al. Receptor signaling in immune cell development and function. Immunol Res 49, 109–123 (2011). https://doi.org/10.1007/s12026-010-8175-9

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