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Phytochemicals in thyroid cancer: analysis of the preclinical studies

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Abstract

Purpose

In the search for novel effective compounds to use in thyroid cancer (TC) unresponsive to current treatment, attention has recently focused on plant-derived compounds with anticancer activity. In this review, we discuss the preclinical studies demonstrating phytochemical activity against thyroid cancer cells.

Results/Conclusions

In particular, we describe their antiproliferative properties or ability to re-induce iodine retention, thus supporting their potential use as single agents or adjuvants in radioiodine-resistant thyroid cancer treatment.

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Acknowledgements

We wish to thank Melissa Kerr for the language revision of the paper.

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Authors and Affiliations

  1. Department of Health Sciences, University “Magna Graecia” of Catanzaro, Viale Europa, Germaneto, 88100, Catanzaro, Italy

    Stefania Bulotta, Francesca Capriglione, Marilena Celano, Diego Russo & Valentina Maggisano

  2. Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    Valeria Pecce

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  1. Stefania Bulotta
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  2. Francesca Capriglione
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Correspondence to Diego Russo.

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Bulotta, S., Capriglione, F., Celano, M. et al. Phytochemicals in thyroid cancer: analysis of the preclinical studies. Endocrine 73, 8–15 (2021). https://doi.org/10.1007/s12020-021-02651-y

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