Phytochemicals in thyroid cancer: analysis of the preclinical studies

Abstract

Purpose

In the search for novel effective compounds to use in thyroid cancer (TC) unresponsive to current treatment, attention has recently focused on plant-derived compounds with anticancer activity. In this review, we discuss the preclinical studies demonstrating phytochemical activity against thyroid cancer cells.

Results/Conclusions

In particular, we describe their antiproliferative properties or ability to re-induce iodine retention, thus supporting their potential use as single agents or adjuvants in radioiodine-resistant thyroid cancer treatment.

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Acknowledgements

We wish to thank Melissa Kerr for the language revision of the paper.

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Correspondence to Diego Russo.

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Bulotta, S., Capriglione, F., Celano, M. et al. Phytochemicals in thyroid cancer: analysis of the preclinical studies. Endocrine (2021). https://doi.org/10.1007/s12020-021-02651-y

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Keywords

  • Phytochemicals
  • Thyroid cancer
  • Combinatory treatment
  • Preclinical studies