, Volume 60, Issue 2, pp 329–338 | Cite as

Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study

  • Yan Han
  • Lei-Jing Mao
  • Xing Ge
  • Kun Huang
  • Shuang-Qin Yan
  • Ling-Ling Ren
  • Shu-Qing Hong
  • Hui Gao
  • Jie Sheng
  • Yuan-Yuan Xu
  • Wei-Jun Pan
  • Peng Zhu
  • Jia-Hu Hao
  • De-Fa Zhu
  • Fang-Biao Tao
Original Article



We aim to investigate associations of maternal serum anti-thyroperoxidase autoantibody (TPOAb) with duration of gestation. We aim to investigate whether maternal TPOAb positivity is associated with the risk of premature or early term birth.


This was a prospective birth cohort study performed in an iodine sufficient area of China. Serum samples were collected from 2931 women at both the first and second trimesters of pregnancy. Thyrotropin (TSH), free thyroxine (FT4), and TPOAb levels were measured. Data on gestational age at birth was obtained from delivery records.


The prevalence of early term birth was 23.8%, while the prevalence of premature birth was 4.2%. The prevalence of TPOAb positivity was 12.1% in the first trimester and was 7.2% in the second trimester. Gestational age at birth was inversely associated with lgTPOAb both in the first trimester (β, −0.283, 95% CI −0.408, −0.158; P < 0.001) and in the second trimester (β, −0.174, 95% CI −0.319, −0.030; P = 0.018), after adjustment for potential confounding factors. There was a positive association of TPOAb positivity with the risk of early term birth both in the first (OR = 1.691, 95% CI 1.302, 2.197) and second trimesters (OR = 1.644, 95% CI 1.193, 2.264), after adjustment for potential confounding factors. TPOAb positivity in the second trimester was associated with a 1.863-fold higher risk of premature birth (OR = 1.863, 95% CI 1.009, 3.441), after adjustment for potential confounding factors.


Our results show that TPOAb is associated with shorter duration of gestation and with higher risk of premature and early term birth.


Thyroid autoantibodies Early term birth Premature birth Pregnancy Birth cohort study 



We appreciate all of the MABC study participants, investigators and staff of Maternal and Child Health Care Center of Ma’anshan for their efforts. This work was supported by the National Natural Science Foundation of China (81330068). This work was supported by the National Natural Science Foundation of China (81330068).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yan Han
    • 1
    • 2
  • Lei-Jing Mao
    • 1
  • Xing Ge
    • 1
  • Kun Huang
    • 1
    • 2
  • Shuang-Qin Yan
    • 3
  • Ling-Ling Ren
    • 4
  • Shu-Qing Hong
    • 1
  • Hui Gao
    • 1
    • 2
  • Jie Sheng
    • 2
  • Yuan-Yuan Xu
    • 1
    • 2
  • Wei-Jun Pan
    • 5
  • Peng Zhu
    • 1
    • 2
  • Jia-Hu Hao
    • 1
    • 2
  • De-Fa Zhu
    • 6
  • Fang-Biao Tao
    • 1
    • 2
  1. 1.Department of Maternal, Child and Adolescent Health, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.Anhui Provincial Key Laboratory of Population Health and AristogenicsHefeiChina
  3. 3.Department of HealthMaternal and Child Health Care Center of Ma’anshanMa’anshanChina
  4. 4.Department of Hygiene Analysis and Detection, School of Public HealthAnhui Medical UniversityHefeiChina
  5. 5.Department of Obstetrics and GynecologyMaternal and Child Health Care Center of Ma’anshanMa’anshanChina
  6. 6.Department of Endocrinology, Anhui Geriatric Institute, The First Affiliated HospitalAnhui Medical UniversityHefeiChina

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