, Volume 59, Issue 1, pp 226–227 | Cite as

Oral mucositis induced by treatment with soft gel formulation of levothyroxine

  • Erika Messina
  • Francesco Ferraù
  • Salvatore Cannavò
Side Effects of Endocrine Treatments


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient.


  1. 1.
    J.V. Hennessey, The emergence of levothyroxine as a treatment for hypothyroidism. Endocrine 55(1), 6–18 (2017)CrossRefPubMedGoogle Scholar
  2. 2.
    C. Virili, P. Trimboli, F. Romanelli, M. Centanni, Liquid and softgel levothyroxine use in clinical practice: state of the art. Endocrine 54(1), 3–14 (2016)CrossRefPubMedGoogle Scholar
  3. 3.
    A.M. Formenti, G. Mazziotti, R. Giubbini, A. Giustina, Treatment of hypothyroidism: all that glitters is gold? Endocrine 52(3), 411–413 (2016)CrossRefPubMedGoogle Scholar
  4. 4.
    R. Vita, P. Fallahi, A. Antonelli, S. Benvenga, The administration of L-thyroxine as soft gel capsule or liquid solution. Expert. Opin. Drug Deliv. 11(7), 1103–1111 (2014)CrossRefPubMedGoogle Scholar
  5. 5.
    F. Lavaee, M. Majd, Evaluation of the association between oral lichen planus and hypothyroidism: a retrospective comparative study. J. Dent. (Shiraz) 17(1), 38–42 (2016)Google Scholar
  6. 6.
    I. Ozdemir, O. Calka, A.S. Karadag, N. Akdeniz, M. Ozturk, Thyroid autoimmunity associated with recurrent aphthous stomatitis. J. Eur. Acad. Dermatol. Venereol. 26(2), 226–230 (2012)CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Clinical and Experimental MedicineUniversity of MessinaMessinaItaly
  2. 2.Department of Human Pathology of Adulthood and ChildhoodUniversity of MessinaMessinaItaly

Personalised recommendations