Skip to main content
Log in

Palbociclib inhibits proliferation of human adrenocortical tumor cells

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig.1

References

  1. A. Berruti, E. Baudin, H. Gelderblom, H.R. Haak, F. Porpiglia, M. Fassnacht, G. Pentheroudakis, ESMO guidelines working group: adrenal cancer: esmo clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 23(Suppl 7), vii131–vii138 (2012)

  2. A.O. Hoff, A. Berruti, Hormone and Cancer 5th International ACC Symposium: future and current therapeutic trials in adrenocortical carcinoma. Horm. Cancer 7, 29–35 (2016)

    Article  CAS  PubMed  Google Scholar 

  3. M.C. De Martino, A. Al Ghuzlan, S. Aubert, G. Assié, J.Y. Scoazec, S. Leboulleux, C. Do Cao, R. Libè, C. Nozières, M. Lombès, F. Pattou, F. Borson-Chazot, S. Hescot, C. Mazoyer, J. Young, I. Borget, A. Colao, R. Pivonello, J.C. Soria, J. Bertherat, M. Schlumberger, L. Lacroix, E. Baudin, Molecular screening for a personalized treatment approach in advanced adrenocortical cancer. J. Clin. Endocrinol. Metab. 98, 4080–4088 (2013)

    Article  PubMed  Google Scholar 

  4. E. Hamilton, J. Infante, Targeting CDK4/6 in patients with cancer. Cancer Treat. Rev. 45, 129–138 (2016)

    Article  CAS  PubMed  Google Scholar 

  5. M.A. Dickson, Molecular pathways: CDK4 inhibitors for cancer therapy. Clin. Cancer Res. 20, 3379–3383 (2014)

    Article  CAS  PubMed  Google Scholar 

  6. S. Verma, C.H. Bartlett, P. Schnell, A.M. DeMichele, S. Loi, J. Ro, M. Colleoni, H. Iwata, N. Harbeck, M. Cristofanilli, K. Zhang, A. Thiele, N.C. Turner, H.S. Rugo,: Palbociclib in combination with fulvestrant in women with hormone receptor-positive/HER2-negative advanced metastatic breast cancer: detailed safety analysis from a multicenter, randomized, placebo-controlled, phase III Study (PALOMA-3). Oncologist 21, 1165–1175 (2016)

  7. S. Sigala, S. Bodei, C. Missale, D. Zani, C. Simeone, S.C. Cunico, P.F. Spano, Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment. Mol. Cell. Endocrinol. 1284, 11–20 (2008)

    Article  Google Scholar 

  8. F. Fiorentini, S. Bodei, F. Bedussi, M. Fragni, S.A. Bonini, C. Simeone, D. Zani, A. Berruti, C. Missale, M. Memo, P.F. Spano, S. Sigala,: GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity. Exp. Cell Res. 323, 100–111 (2014)

  9. I. Casaburi, P. Avena, A. De Luca, A. Chimento, R. Sirianni, R. Malivindi, V. Rago, M. Fiorillo, F. Domanico, C. Campana, A.R. Cappello, F. Sotgia, M.P. Lisanti, V. Pezzi, Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget 22, 25135–25148 (2015)

    Google Scholar 

  10. R. Roskoski, Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs. Pharmacol. Res. 107, 249–275 (2016)

    Article  CAS  PubMed  Google Scholar 

  11. N.J. Dyson, RB1: a prototype tumor suppressor and an enigma. Genes Dev. 30, 1492–1502 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. M. Malumbres, M. Barbacid, Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630–641 (2005)

    Article  CAS  PubMed  Google Scholar 

  13. G. Assié, E. Letouzé, M. Fassnacht, A. Jouinot, W. Luscap, O. Barreau, H. Omeiri, S. Rodriguez, K. Perlemoine, F. René-Corail, N. Elarouci, S. Sbiera, M. Kroiss, B. Allolio, J. Waldmann, M. Quinkler, M. Mannelli, F. Mantero, T. Papathomas, R. De Krijger, A. Tabarin, V. Kerlan, E. Baudin, F. Tissier, B. Dousset, L. Groussin, L. Amar, E. Clauser, X. Bertagna, B. Ragazzon, F. Beuschlein, R. Libé, A. de Reyniès, J. Bertherat, Integrated genomic characterization of adrenocortical carcinoma. Nat. Genet. 46, 607–612 (2014)

    Article  PubMed  Google Scholar 

  14. B. Ragazzon, R. Libé, G. Assié, F. Tissier, O. Barreau, C. Houdayer, K. Perlemoine, A. Audebourg, E. Clauser, F. René-Corail, X. Bertagna, B. Dousset, J. Bertherat, L. Groussin, Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas. Eur. J. Endocrinol. 170, 385–391 (2014)

    Article  CAS  PubMed  Google Scholar 

  15. J.T. Hoffman, A. Plotka, M. O'Gorman, A. Chang, M. Kosa, C.M. Loi, C. Gallo-Stampino, D.D. Wang,: A phase 1 randomized, open-label, fixed-sequence, 2-period study of the effect of multiple doses of rifampin on palbociclib (PD-0332991) pharmacokinetics in healthy volunteers. ASCO Annual Meeting, Philadelphia, 18–22, (2015)

  16. D.B. Rivadeneira, C.N. Mayhew, C. Thangavel, E. Sotillo, C.A. Reed, X. Graña, E.S. Knudsen, Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology 138, 1920–1930 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. M. Fraenkel, M. Gueorguiev, D. Barak, A. Salmon, A.B. Grossman, D.J. Gross, Everolimus therapy for progressive adrenocortical cancer. Endocrine 44, 187–192 (2013)

    Article  CAS  PubMed  Google Scholar 

  18. M.C. De Martino, P.M. van Koetsveld, R.A. Feelders, S.W. Lamberts, W.W. de Herder, A. Colao, R. Pivonello, L.J. Hofland, Effects of combination treatment with sirolimus and mitotane on growth of human adrenocortical carcinoma cells. Endocrine 52, 664–667 (2016)

    Article  PubMed  Google Scholar 

  19. C. Fiorentini, M. Fragni, P. Perego, S. Vezzoli, S.A. Bonini, M. Tortoreto, D. Galli, M. Claps, G.A. Tiberio, M. Terzolo, C. Missale, M. Memo, G. Procopio, N. Zaffaroni, A. Berruti, S. Sigala, Antisecretive and antitumor activity of abiraterone acetate in human adrenocortical cancer: a preclinical study. J. Clin. Endocrinol. Metab. 101, 4594–4602 (2016)

    Article  CAS  PubMed  Google Scholar 

  20. A. Berruti, M. Terzolo, P. Sperone, A. Pia, S. Della Casa, D.J. Gross, C. Carnaghi, P. Casali, F. Porpiglia, F. Mantero, G. Reimondo, A. Angeli, L. Dogliotti, Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial. Endocr. Relat. Cancer 12, 657–666 (2005)

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by University of Brescia local grants; AIRC, project IG17678; Fondazione Camillo Golgi and by a private donation of Mrs Serena Ambrogini and family in memory of her son Guido Cioni. M.F. was supported by a grant from the Italian Society of Pharmacology. Palbociclib was kindly provided by Pfizer.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alfredo Berruti.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest in relation to the topic of the manuscript.

Ethical approval

The project was approved by the local Ethical Committee.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Chiara Fiorentini and Martina Fragni equally contributed to this work

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fiorentini, C., Fragni, M., Tiberio, G.A. et al. Palbociclib inhibits proliferation of human adrenocortical tumor cells. Endocrine 59, 213–217 (2018). https://doi.org/10.1007/s12020-017-1270-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-017-1270-0

Navigation