References
A. Berruti, E. Baudin, H. Gelderblom, H.R. Haak, F. Porpiglia, M. Fassnacht, G. Pentheroudakis, ESMO guidelines working group: adrenal cancer: esmo clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 23(Suppl 7), vii131–vii138 (2012)
A.O. Hoff, A. Berruti, Hormone and Cancer 5th International ACC Symposium: future and current therapeutic trials in adrenocortical carcinoma. Horm. Cancer 7, 29–35 (2016)
M.C. De Martino, A. Al Ghuzlan, S. Aubert, G. Assié, J.Y. Scoazec, S. Leboulleux, C. Do Cao, R. Libè, C. Nozières, M. Lombès, F. Pattou, F. Borson-Chazot, S. Hescot, C. Mazoyer, J. Young, I. Borget, A. Colao, R. Pivonello, J.C. Soria, J. Bertherat, M. Schlumberger, L. Lacroix, E. Baudin, Molecular screening for a personalized treatment approach in advanced adrenocortical cancer. J. Clin. Endocrinol. Metab. 98, 4080–4088 (2013)
E. Hamilton, J. Infante, Targeting CDK4/6 in patients with cancer. Cancer Treat. Rev. 45, 129–138 (2016)
M.A. Dickson, Molecular pathways: CDK4 inhibitors for cancer therapy. Clin. Cancer Res. 20, 3379–3383 (2014)
S. Verma, C.H. Bartlett, P. Schnell, A.M. DeMichele, S. Loi, J. Ro, M. Colleoni, H. Iwata, N. Harbeck, M. Cristofanilli, K. Zhang, A. Thiele, N.C. Turner, H.S. Rugo,: Palbociclib in combination with fulvestrant in women with hormone receptor-positive/HER2-negative advanced metastatic breast cancer: detailed safety analysis from a multicenter, randomized, placebo-controlled, phase III Study (PALOMA-3). Oncologist 21, 1165–1175 (2016)
S. Sigala, S. Bodei, C. Missale, D. Zani, C. Simeone, S.C. Cunico, P.F. Spano, Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment. Mol. Cell. Endocrinol. 1284, 11–20 (2008)
F. Fiorentini, S. Bodei, F. Bedussi, M. Fragni, S.A. Bonini, C. Simeone, D. Zani, A. Berruti, C. Missale, M. Memo, P.F. Spano, S. Sigala,: GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity. Exp. Cell Res. 323, 100–111 (2014)
I. Casaburi, P. Avena, A. De Luca, A. Chimento, R. Sirianni, R. Malivindi, V. Rago, M. Fiorillo, F. Domanico, C. Campana, A.R. Cappello, F. Sotgia, M.P. Lisanti, V. Pezzi, Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget 22, 25135–25148 (2015)
R. Roskoski, Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs. Pharmacol. Res. 107, 249–275 (2016)
N.J. Dyson, RB1: a prototype tumor suppressor and an enigma. Genes Dev. 30, 1492–1502 (2016)
M. Malumbres, M. Barbacid, Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630–641 (2005)
G. Assié, E. Letouzé, M. Fassnacht, A. Jouinot, W. Luscap, O. Barreau, H. Omeiri, S. Rodriguez, K. Perlemoine, F. René-Corail, N. Elarouci, S. Sbiera, M. Kroiss, B. Allolio, J. Waldmann, M. Quinkler, M. Mannelli, F. Mantero, T. Papathomas, R. De Krijger, A. Tabarin, V. Kerlan, E. Baudin, F. Tissier, B. Dousset, L. Groussin, L. Amar, E. Clauser, X. Bertagna, B. Ragazzon, F. Beuschlein, R. Libé, A. de Reyniès, J. Bertherat, Integrated genomic characterization of adrenocortical carcinoma. Nat. Genet. 46, 607–612 (2014)
B. Ragazzon, R. Libé, G. Assié, F. Tissier, O. Barreau, C. Houdayer, K. Perlemoine, A. Audebourg, E. Clauser, F. René-Corail, X. Bertagna, B. Dousset, J. Bertherat, L. Groussin, Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas. Eur. J. Endocrinol. 170, 385–391 (2014)
J.T. Hoffman, A. Plotka, M. O'Gorman, A. Chang, M. Kosa, C.M. Loi, C. Gallo-Stampino, D.D. Wang,: A phase 1 randomized, open-label, fixed-sequence, 2-period study of the effect of multiple doses of rifampin on palbociclib (PD-0332991) pharmacokinetics in healthy volunteers. ASCO Annual Meeting, Philadelphia, 18–22, (2015)
D.B. Rivadeneira, C.N. Mayhew, C. Thangavel, E. Sotillo, C.A. Reed, X. Graña, E.S. Knudsen, Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology 138, 1920–1930 (2010)
M. Fraenkel, M. Gueorguiev, D. Barak, A. Salmon, A.B. Grossman, D.J. Gross, Everolimus therapy for progressive adrenocortical cancer. Endocrine 44, 187–192 (2013)
M.C. De Martino, P.M. van Koetsveld, R.A. Feelders, S.W. Lamberts, W.W. de Herder, A. Colao, R. Pivonello, L.J. Hofland, Effects of combination treatment with sirolimus and mitotane on growth of human adrenocortical carcinoma cells. Endocrine 52, 664–667 (2016)
C. Fiorentini, M. Fragni, P. Perego, S. Vezzoli, S.A. Bonini, M. Tortoreto, D. Galli, M. Claps, G.A. Tiberio, M. Terzolo, C. Missale, M. Memo, G. Procopio, N. Zaffaroni, A. Berruti, S. Sigala, Antisecretive and antitumor activity of abiraterone acetate in human adrenocortical cancer: a preclinical study. J. Clin. Endocrinol. Metab. 101, 4594–4602 (2016)
A. Berruti, M. Terzolo, P. Sperone, A. Pia, S. Della Casa, D.J. Gross, C. Carnaghi, P. Casali, F. Porpiglia, F. Mantero, G. Reimondo, A. Angeli, L. Dogliotti, Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial. Endocr. Relat. Cancer 12, 657–666 (2005)
Acknowledgements
This work was supported by University of Brescia local grants; AIRC, project IG17678; Fondazione Camillo Golgi and by a private donation of Mrs Serena Ambrogini and family in memory of her son Guido Cioni. M.F. was supported by a grant from the Italian Society of Pharmacology. Palbociclib was kindly provided by Pfizer.
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Chiara Fiorentini and Martina Fragni equally contributed to this work
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Fiorentini, C., Fragni, M., Tiberio, G.A. et al. Palbociclib inhibits proliferation of human adrenocortical tumor cells. Endocrine 59, 213–217 (2018). https://doi.org/10.1007/s12020-017-1270-0
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DOI: https://doi.org/10.1007/s12020-017-1270-0