Skip to main content

Table 2 Changes in selected apoptotic genes’ expression in OVCAR-3 cells following exposure to 40 ng/ml leptin for 24 h

From: Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells

Assay ID Transcript Description Gene symbol Average fold change
Extrinsic pathway
 102679 ENST00000162749 Tumor necrosis factor receptor superfamily member 1A precursor (p60) TNFR1 −1.8***
 100426 ENST00000371875 Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) FAS −1.1
 100417 ENST00000301838 Protein FADD (FAS-associated death domain protein) FADD −1.54**
 100289 ENST00000332896 Death domain-containing protein CRADD (caspase and RIP adapter with death domain) CRADD 1.0
 100227 ENST00000358485 Caspase-8 precursor CASP8 −1.1
 100204 ENST00000272879 Caspase-10 precursor CASP10 −1.45**
 100210 ENST00000310447 Caspase-2 precursor CASP2 1.0
Intrinsic pathway
 Pro-survival
  100083 ENST00000398117 Apoptosis regulator Bcl-2 BCL2 1.0
  104039 ENST00000250405 Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) BCLW 1.0
  100088 ENST00000307677 Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) BCLX 1.0
  102930 ENST00000369026 Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1) MCL1 1.0
 Pro-apoptotic
  104034 ENST00000394532 Bcl2 antagonist of cell death (BAD) BAD −2.1***
  100068 ENST00000374467 Bcl-2 homologous antagonist/killer (apoptosis regulator BAK) BAK1 −1.5**
  102861 ENST00000293288 Apoptosis regulator BAX BAX −1.3*
  100122 ENST00000342111 BH3-interacting domain death agonist (BID) BID −1.2*
  100126 ENST00000216115 Bcl-2-interacting killer (Apoptosis inducer NBK) BIK 1.0
  100165 ENST00000318407 Bcl-2-related ovarian killer protein (Hbok) BOK −1.8***
  100233 ENST00000333868 Caspase-9 precursor CASP9 −1.2*
  102892 ENST00000333991 Apoptotic protease-activating factor 1 (Apaf-1) APAF1 −1.8***
  100213 ENST00000308394 Caspase-3 precursor CASP3 −1.3*
  100222 ENST00000265164 Caspase-6 precursor CASP6 −2.0***
  100224 ENST00000369331 Caspase-7 precursor CASP7 −1.5**
  102620 ENST00000264705 CAD protein CAD −1.25*
  102630 ENST00000377038 DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) ICAD −1.25*
Caspase-independent pathway
 102632 ENST00000372642 Endonuclease G, mitochondrial precursor ENDOG 1.0
 101277 ENST00000396473 Cellular tumor antigen p53 (Tumor suppressor p53) TP53 1.0
  1. Values are mean ± SEM. *,**,*** Significantly different from control at P < 0.05, P < 0.01, and P < 0.001, respectively. Control value = 1.0