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Table 1 Changes in selected cell cycle genes’ expression in OVCAR-3 cells exposed to 40 ng/ml leptin for 24 h

From: Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells

Assay ID Transcript Description Gene symbol Average fold change
G1/S phase
 100844 ENST00000227507 G1/S-specific cyclin-D1 (PRAD1 oncogene) CCND1 1.3*
 102813 ENST00000372991 G1/S-specific cyclin-D3 CCND3 1.0
 101418 ENST00000257904 Cell division protein kinase 4 CDK4 1.0
 101427 ENST00000265734 Cell division protein kinase 6 CDK6 1.0
 100848 ENST00000262643 G1/S-specific cyclin-E1 CCNE1 1.0
 100850 ENST00000308108 G1/S-specific cyclin-E2 CCNE2 1.0
 101416 ENST00000266970 Cell division protein kinase 2 CDK2 1.0
 101538 ENST00000267163 Retinoblastoma-associated protein (pRb) RB1 1.0
 102827 ENST00000343380 Transcription factor E2F1 (E2F-1) E2F1 1.0
 102830 ENST00000361729 Transcription factor E2F2 (E2F-2) E2F2 1.0
 102834 ENST00000346618 Transcription factor E2F3 (E2F-3) E2F3 1.2*
 101524 ENST00000379160 Proliferating cell nuclear antigen (PCNA) PCNA 1.2*
G2/M phase
 102811 ENST00000274026 Cyclin-A2 (cyclin-A) CCNA2 1.3*
 101373 ENST00000256442 G2/mitotic-specific cyclin-B1 CCNB1 1.1
 101376 ENST00000288207 G2/mitotic-specific cyclin-B2 CCNB2 1.0
 101406 ENST00000293968 Cell division control protein 2 homolog CDK1 1.0
 102820 ENST00000302506 M-phase inducer phosphatase 1 CDC25A 1.0
 102823 ENST00000245960 M-phase inducer phosphatase 2 CDC25B 1.15
 102826 ENST00000323760 M-phase inducer phosphatase 3 CDC25C 1.0
 102849 ENST00000299613 Wee1-like protein kinase WEE1 1.0
Cell cycle progresion inhibitors
 102909 ENST00000244741 Cyclin-dependent kinase inhibitor 1 (p21) P21CIP1 −1.9**
 100855 ENST00000228872 Cyclin-dependent kinase inhibitor 1B (cyclin-dependent kinase inhibitor p27) P27KIP1 −1.2*
 101471 ENST00000370986 Growth arrest and DNA-damage-inducible protein GADD45 alpha (DNA-damage-inducible transcript 1) GADD45A −1.2*
  1. Values are mean ± SEM. *,** Significantly different from control at P < 0.5 and P < 0.001, respectively. Control value = 1.0