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Innate B Cells: the Archetype of Protective Immune Cells

  • Alexis Grasseau
  • Marina Boudigou
  • Laëtitia Le Pottier
  • Nedra Chriti
  • Divi Cornec
  • Jacques-Olivier Pers
  • Yves Renaudineau
  • Sophie HillionEmail author
Article

Abstract

The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response.

Keywords

Innate B cells Effector functions IgM Autoreactivity Regulatory B cells 

Notes

Acknowledgments

We are thankful to Dr. Wesley H. Brooks (University of South Florida, USA) for editorial assistance and to Simone Forest and Genevieve Michel for secretarial assistance.

Funding

All authors work in a department supported by the Brest University, CHU Brest, and INSERM.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

Ethical approval is not applicable as this is a review article.

Informed Consent

Informed consent is not applicable as this is a review article.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Alexis Grasseau
    • 1
  • Marina Boudigou
    • 1
  • Laëtitia Le Pottier
    • 1
  • Nedra Chriti
    • 1
  • Divi Cornec
    • 1
  • Jacques-Olivier Pers
    • 1
  • Yves Renaudineau
    • 1
    • 2
  • Sophie Hillion
    • 1
    • 2
    Email author
  1. 1.UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERMCHU de BrestBrestFrance
  2. 2.Laboratory of Immunology and ImmunotherapyCHU BrestBrestFrance

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