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Clinical Reviews in Allergy & Immunology

, Volume 54, Issue 3, pp 353–365 | Cite as

Mast Cell Activation Syndrome

  • Marianne Frieri
Article

Abstract

Mast cell activation syndrome (MCAS) involves the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems, classified as primary, secondary, and idiopathic. Earlier criteria for MCAS diagnosis included episodic symptoms with mast cell mediators affecting two or more organ systems with urticaria, angioedema, flushing, nausea, vomiting, diarrhea, abdominal cramping, hypotensive syncope, tachycardia, wheezing, conjunctival injection, pruritus, nasal stuffiness, decrease in frequency, severity, or resolution of symptoms with anti-mediator therapy including H1/H2 receptor antagonists, anti-leukotrienes, or mast cell stabilizers. Laboratory data includes an increased validated urinary or serum markers of MCAS, documentation of an increase of the marker above the patient’s baseline value during symptomatic periods on more than two occasions, or baseline serum tryptase levels that are persistently above 15 ng/mL. Laboratory data also includes an increase of the tryptase level above baseline value on one occasion. Other assays are 24-h urine histamine metabolites, PGD2 or its metabolite, and 11-β-prostaglandin F2 alpha. A recent global classification is a response of clinical symptoms, a substantial transient increase in serum total tryptase or increase in other mast cell-derived mediators, histamine or PGD2 or urinary metabolites, and agents that attenuate production or mast cell mediator activities. “Spectrum of MCAS disorders” has been proposed, highlighting symptoms’ diagnostic tests and treatments.

Keywords

Mast cells Mast cell activation syndrome (MCAS) anaphylaxis Tryptase Mastocytosis Non-clonal MCAS Omalizumab Ketotifen 

Notes

Ethical Statement

I have no grant support or any conflict of interest for this review.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of MedicineNassau University Medical Center, an affiliate of North Shore Long Island Jewish (NSLIJ) Health Care SystemsEast MeadowUSA

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