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MicroRNAs in the Migration of Mesenchymal Stem Cells

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Abstract

Mesenchymal stem cells (MSCs) represent a promising source of cell-based therapies for treatment of a wide variety of injuries and diseases. Their tropism and migration to the damaged sites, which are elicited by cytokines secreted from tissues around pathology, are the prerequisite for tissue repair and regeneration. Better understanding of the elicited-migration of MSCs and discovering conditions that elevate their migration ability, will help to increase their homing to pathologies and improve therapeutic efficacy. It is increasingly recognized that microRNAs are important regulators of cell migration. Here we summarize current understanding of the microRNA-regulated migration of MSCs.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant no. 31371407, 30870642) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Funding

This contribution is supported by the National Natural Science Foundation of China (Grant no. 31371407, 30870642) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Suzhou, 215123, China

    Lihong He & Huanxiang Zhang

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He, L., Zhang, H. MicroRNAs in the Migration of Mesenchymal Stem Cells. Stem Cell Rev and Rep 15, 3–12 (2019). https://doi.org/10.1007/s12015-018-9852-7

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