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Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases

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Abstract

Mesenchymal stem cells (MSCs) are promising resource for the therapy of inflammatory bowel diseases (IBDs) on the grounds of their differentiation capabilities and immuno-modulatory characteristics. Results of clinical studies indicate that local application of MSCs is a secure and beneficial approach for the treatment of perianal fistulas while systemic application of MSCs leads to the attenuation or aggravation of IBDs. Herein, we emphasized molecular mechanisms and approaches that should improve efficacy of MSC-based therapy of IBDs.

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Acknowledgements

This study was supported by Serbian Ministry of Science (ON175069, ON175103) and Faculty of Medical Sciences University of Kragujevac (JP02/09).

The authors would like to express their thanks to Nemanja Jovicic who created figures.

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Authors and Affiliations

  1. Faculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia

    Bojana Simovic Markovic, Nebojsa Arsenijevic & Vladislav Volarevic

  2. Faculty of Medical Sciences, Department of Dentistry, University of Kragujevac, Serbia, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia

    Tatjana Kanjevac

  3. Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL, USA

    C. Randall Harrell & Crissy Fellabaum

  4. Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, Serbia, Kragujevac, Serbia

    Marina Gazdic

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  1. Bojana Simovic Markovic
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Correspondence to Vladislav Volarevic.

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Markovic, B.S., Kanjevac, T., Harrell, C.R. et al. Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases. Stem Cell Rev and Rep 14, 153–165 (2018). https://doi.org/10.1007/s12015-017-9789-2

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