Stem Cell Reviews and Reports

, Volume 14, Issue 2, pp 213–222 | Cite as

Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™)

  • Vinaykumar Tripathi
  • Sagar Chhabria
  • Vaibhav Jadhav
  • Deepa Bhartiya
  • Ashish Tripathi


Resveratrol generated enormous interest as it improved functions of multiple organs and could delay aging in animal models. However, basic mechanism of action was not understood and due to poor bioavailability, it has failed to enter the market. A highly active nano-formulation of resveratrol (XAR™) with enhanced bioavailability is now available. Present study was undertaken to evaluate its effects on stem cells biology in the human peripheral blood. Twelve healthy participants were enrolled of which five received XAR™, five were age-matched placebo controls and two were 76 and 85 years old. Peripheral blood was processed to study serum profile to monitor cardiac and pancreatic functions and subjected to density gradient centrifugation to enrich pluripotent (VSELs) and adult stem cells that get enriched along with red blood cells and in the Buffy coat respectively on Day 2 and Day 15 after XAR™ treatment. The XAR™ treatment resulted in an increased expression of pluripotency transcripts specific for VSELs (Oct-4A, Nanog and Sox2) on D2; specific transcripts for differentiation in the progenitors including Oct-4, Ikaros, CD14, CD90 on D15, and anti-ageing and tumor suppressor transcripts NAD, SIRT1, SIRT6 and p53 in both stem cells and progenitors. An improvement of cardiac and pancreatic markers in serum profile was also observed on D15. The decline in VSELs numbers with age and beneficial effects of the XAR™ treatment were evident by up-regulation of specific transcripts and on serum profile. XAR™ is a promising molecule that has the potential to activate pluripotent VSELs and tissue committed adult stem cells ‘progenitors’ resulting in the rejuvenation of various body tissues and for improved, cancer-free health with advanced age.


Stem cells VSELs Resveratrol OCT-4 Regeneration Aging Tumor suppression 


Compliance with Ethical Standards

Conflict of Interest

VT, SC, VJ and AT are affiliated to Epigeneres Biotech Pvt. Ltd. which manufactures and has patented XAR™.

Supplementary material

12015_2017_9784_MOESM1_ESM.docx (100 kb)
Supplementary material 1 (DOCX 100 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Vinaykumar Tripathi
    • 1
  • Sagar Chhabria
    • 1
  • Vaibhav Jadhav
    • 1
  • Deepa Bhartiya
    • 2
  • Ashish Tripathi
    • 1
  1. 1.Epigeneres Biotech Pvt. Ltd.MumbaiIndia
  2. 2.Stem Cell Biology DepartmentICMR-National Institute for Research in Reproductive HealthMumbaiIndia

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