Stem Cell Reviews and Reports

, Volume 14, Issue 2, pp 177–188 | Cite as

3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

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Abstract

There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of ex vivo human primary pancreatic islets and developments into the generation of stem cell derived pancreatic beta-cells (β-cells). Special attention will be given to recent approaches combining the use of extracellular matrix (ECM) scaffolds with pancreatic molecular memory, which can be used to improve yield and functionality of in vitro stem cell-derived pancreatic models. The ultimate goal is to develop scalable cell-based platforms for diabetes research and drug screening. This article will critically assess key aspects related to in vitro pancreatic 3D-ECM models and highlight the most promising approaches for future research.

Keywords

Human pancreatic islets Stem cell-derived β-cells Insulin GSIS 3D-models Pancreatic ECM Decellularized scaffolds 

Abbreviations

DM

Diabetes mellitus

T1DM

Type 1 diabetes mellitus

T2DM

Type 2 diabetes mellitus

Islets

Islets of Langerhans

β-cells

Beta-cells

INS

Insulin

C-PEP

C-Peptide

GSIS

Glucose-stimulated INS secretion

ESCs

Embryonic stem cell

iPSC

Induced pluripotent stem cell

MSCs

Mesenchymal stem cells

ECM

Extracellular matrix

BM

Basement membrane

COL

Collagen

LN

Laminin

3D

3-dimensional

Notes

Acknowledgements

DR is funded by the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7 (2007–2013) under REA grant agreement n˚ [607842]. PW-S also acknowledge the Wallenberg Foundation, Chalmers Foundation and the Swedish Research Council.

Authors’ Contributions

All authors contributed to concept development and writing of this text.

Compliance with Ethical Standards

Disclosure Statement

The authors declare a conflict of interest. DR, AK, RH and AF are employees and shareholders of AstraZeneca. PW-S is employed by Chalmers University of Technology and funded described in the acknowledge section. The funders did not have any role in the decision to publish or preparation of the manuscript.

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© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Discovery Sciences, Innovative Medicines and Early Development Biotech UnitAstraZenecaGothenburgSweden
  2. 2.Department of Biology and BioengineeringChalmers University of TechnologyGothenburgSweden

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