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Transforming Growth Factor Beta (TFG-β) Concentration Isoforms are Diminished in Acute Coronary Syndrome

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Abstract

Acute coronary syndrome (ACS) is the leading cause of death in elderly patients worldwide. Due its participation in apoptosis, fibrosis, and angiogenesis, transforming growth factor-β (TGF-β) isoforms had been categorized as risk factors for cardiovascular diseases. However, due their contradictory activities, a cardioprotective role has been suggested. The aim was to measure the plasma levels of TGF-β1, 2, and 3 proteins in patients with ACS. This was a case–control study including 225 subjects. The three activated isoforms were measured in serum using the Bio-Plex Pro TGF-β assay by means of magnetic beads; the fluorescence intensity of reporter signal was read in a Bio-Plex Magpix instrument. We observed a significant reduction of the three activated isoforms of TGF-β in patients with ACS. The three TGF-β isoforms were positively correlated with each other in moderate-to-strong manner. TGFβ-2 was inversely correlated with glucose and low-density lipoprotein (LDL)-cholesterol, whereas TGF-β3 was inversely correlated with the serum cholesterol concentration. The production of TGF-β1, TGF-β2, and TGF-β3 are decreased in the serum of patients with ACS. Further follow-up controlled studies with a larger sample size are needed, in order to test whether TGF-β isoforms could be useful as biomarkers that complement the diagnosis of ACS.

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Acknowledgements

The authors thank all of the participants in this study

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Authors and Affiliations

  1. Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    Jorge Ramón Padilla-Gutiérrez, Emmanuel Valdés-Alvarado, Saraí Citlalic Rodríguez-Reyes & José Francisco Muñoz Valle

  2. Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    Saraí Citlalic Rodríguez-Reyes

  3. Especialidad en Cardiología IMSS, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico

    Juan Arellano-Martin & Héctor Enrique Flores-Salinas

  4. Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente, Departamento de Cardiología, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico

    Héctor Enrique Flores-Salinas

  5. Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    Yeminia Valle

Authors
  1. Jorge Ramón Padilla-Gutiérrez
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  2. Emmanuel Valdés-Alvarado
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  3. Saraí Citlalic Rodríguez-Reyes
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  5. Héctor Enrique Flores-Salinas
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  6. José Francisco Muñoz Valle
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  7. Yeminia Valle
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Correspondence to Yeminia Valle.

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Padilla-Gutiérrez, J.R., Valdés-Alvarado, E., Rodríguez-Reyes, S.C. et al. Transforming Growth Factor Beta (TFG-β) Concentration Isoforms are Diminished in Acute Coronary Syndrome. Cell Biochem Biophys 76, 433–439 (2018). https://doi.org/10.1007/s12013-018-0849-2

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  • DOI: https://doi.org/10.1007/s12013-018-0849-2

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