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Effect of Subthalamic Nuclei Electrical Stimulation in the Treatment of Parkinson’s Disease

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Abstract

The aim of this study was to evaluate the clinical efficacy of deep brain stimulation (DBS) and subthalamic nuclei stimulation (STN) in the treatment of Parkinson’s disease. A total of 32 patients with Parkinson’s disease who continuously treated in our hospital with STN–DBS from November 2011 to November 2013 were selected. All the patients received follow-up evaluation, psychological status questionnaire survey and analysis before surgery and 3 months after surgery using unified Parkinson’s disease rating scale (UPDRS), Self-rating depression scale (SDS), and symptom checklist (SCL-90). After turned on the impulse generator (IPG), the daily activities and motor function of UPDRS in all the 32 cases of Parkinson’s disease patients were in “turn off” state; the mean improvement rates were 51.7 and 60.9 %; when the daily activities and motor function in the state of “turn on”, the mean improvement rates were 21.4 and 22.3 %. In 20 cases, the preoperative SDS > 50, the levels of depression, anxiety, somatization, interpersonal sensitivity, hostility, fear, and paranoia of SCL-90 were significant higher than the Chinese traditional levels (P < 0.05). Comparison of the preoperative and postoperative depression, somatization, fear, anxiety, and psychotic factor of SCL-90 found that there was negative correlation between preoperation and postoperation, and the differences were significant (P < 0.05), while there were no significant differences in interpersonal sensitivity and paranoia (P > 0.05). STN–DBS can improve the motor function and ability of daily life of Parkinson’s disease patients and can significantly improve the psychological condition of the patients with Parkinson’s disease and depression; it is a safe and effective method to the treatment of Parkinson’s disease.

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Authors and Affiliations

  1. Department of Neurosurgery, General Hospital of Shenyang Military Area Command, No. 83, Wenhua Road, Shenhe District, Shenyang, 110840, China

    Yingqun Tao & Guobiao Liang

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  1. Yingqun Tao
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  2. Guobiao Liang
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Correspondence to Yingqun Tao.

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Tao, Y., Liang, G. Effect of Subthalamic Nuclei Electrical Stimulation in the Treatment of Parkinson’s Disease. Cell Biochem Biophys 71, 113–117 (2015). https://doi.org/10.1007/s12013-014-0169-0

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  • DOI: https://doi.org/10.1007/s12013-014-0169-0

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