Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials


The prevalence of cardiometabolic risk factors has been increasing worldwide. The results of reported studies on the effects of zinc supplementation on cardiometabolic risk factors are unequivocal. This systematic review and meta-analysis of randomized controlled trials was conducted to evaluate the effects of zinc supplementation on cardiometabolic risk factors. A systematic search was conducted through international databases (PubMed/Medline, Institute of Scientific Information, and Scopus) until December 2018 to include all randomized controlled trials (RCT), quasi-RCT, and controlled clinical trials which assessed the effect of zinc supplementation on cardiometabolic risk factors including lipid profile, glycemic indices, blood pressure, and anthropometric indices. Random- or fixed-effects meta-analysis method was used to estimate the standardized mean difference (SMD) and 95% confidence interval (CI). A total of 20 studies were included in the meta-analysis, which included a total of 1141 participants in the intervention group. Meta-analysis showed that zinc supplementation significantly decreased plasma levels of triglyceride (SMD − 0.66, 95% CI − 1.27, − 0.06), very-low-density lipoprotein (SMD − 1.59, 95% CI − 2.86, − 0.31), and total cholesterol (SMD − 0.65, 95% CI − 1.15, − 0.15). Similarly, zinc supplementation significantly decreased fasting blood glucose (SMD − 0.52, 95% CI − 0.96, − 0.07) and HbA1c (SMD − 0.64, 95% CI − 1.27, − 0.02). The effects of zinc supplementation on blood pressure and anthropometric indices were not statistically significant (P > 0.05). Zinc supplements had beneficial effects on glycemic indices and lipid profile. Thus, it appeared that zinc supplementation might be associated with a decrease in cardiometabolic risk factors contributing to a reduction in risk of atherosclerosis.

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The authors are thankful to the Emam Ali Clinical Research Development Unit for the assistance.


This study was funded by Alborz University of Medical Sciences.

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MQ, MGH, MKH, and SD designed the research; SM and HA conducted the research; PT analyzed the data; MN, AA, and FS wrote the paper. All authors read and approved the final manuscript.

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Correspondence to Mostafa Qorbani.

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The present study was approved by the ethical committee of Alborz University of Medical Sciences.

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Table 6 Risk of bias assessment in the randomized controlled trials

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Khazdouz, M., Djalalinia, S., Sarrafi Zadeh, S. et al. Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Biol Trace Elem Res 195, 373–398 (2020). https://doi.org/10.1007/s12011-019-01870-9

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  • Metabolic syndrome
  • Cardiometabolic risk factors
  • Zinc supplementation
  • Meta-analysis
  • Systematic review