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Is Iron Accumulation a Possible Risk Factor for Sarcopenia?

  • Guoyang Zhao
Article

Abstract

Sarcopenia has a high incidence among the elderly, with significant negative effects on the quality of life. The pathogenesis of sarcopenia is complex, and many factors are involved in its development and progression. Sarcopenia might be associated with iron accumulation given that (1) age-related iron accumulation was found in the skeletal muscle, (2) excess iron could cause skeletal muscle damage or atrophy, and (3) patients with sarcopenia showed higher levels of serum ferritin. Understanding the etiology and pathogenesis of sarcopenia would help to develop new treatment and preventive methods, thereby improving the quality of life of the elderly patients.

Keywords

Sarcopenia Iron accumulation Skeletal muscle Ferritin 

Abbreviations

DMT1

divalent metal transporter 1

HJV

hemojuvelin

TfR1

transferrin receptor 1

IRP2

iron regulatory protein 2

FPN1

ferroportin 1

ROS

reactive oxygen species

Notes

Funding Information

This work was partially supported by the Jiangsu provincial key research and development program (No. BE2016720), and Jiangsu provincial maternal and child health program (No. F201506).

Compliance with Ethical Standards

Conflict of Interest

The author declares that there is no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of OrthopaedicsThe Affiliated Hospital of Jiangsu UniversityZhenjiangChina

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