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Associations Between Copper and Zinc and Risk of Hypertension in US Adults

  • Jie Yao
  • Ping Hu
  • Dongfeng Zhang
Article
  • 124 Downloads

Abstract

Evidence linking copper and zinc to hypertension are limited and conflicting. Data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 were used. Zinc and copper intake from diet and supplements was assessed with 24-h dietary recall. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg/diastolic blood pressure (DBP) ≥ 90 mmHg/treatment with hypertensive medications. In a sensitivity analysis, according to the 2017 American College of Cardiology and American Heart Association guideline, hypertension was also defined as SBP ≥ 130 mmHg/DBP ≥ 80 mmHg/treatment with hypertensive medications. A total of 17,811 adults (8430 men and 9381 women) were included. After adjustment for age, gender, body mass index (BMI), race, educational level, smoking status, family income, and total daily energy intake, the OR of hypertension for highest vs. lowest quartile intake of copper, zinc, and copper/zinc ratio was 1.11 (0.90–1.37), 1.11 (0.90–1.35), and 0.95 (0.81–1.11), respectively. In stratified analysis by BMI (< 25 kg/m2, 25–30 kg/m2, > 30 kg/m2), no significant association was found between hypertension and intakes of copper, zinc, and copper/zinc ratio (highest vs. lowest quartile) in multivariate analysis. In multivariate analysis, the OR of hypertension for highest vs. lowest quartile levels of serum copper, zinc, and copper/zinc ratio was 1.11 (0.61–2.04), 1.43 (0.84–2.44), and 0.68 (0.34–1.33), respectively. Similar results were found in the sensitivity analysis. Zinc and copper might be not independently associated with hypertension in US adults.

Keywords

Zinc Copper Copper/zinc ratio Hypertension 

Notes

Acknowledgments

We thank all staffs at the National Center for Health Statistics of the Centers for Disease Control and Prevention who were responsible for the planning and administering of NHANES and making the datasets of NHANES available on the website.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

For this type of study, formal consent is not required

Supplementary material

12011_2018_1320_MOESM1_ESM.doc (256 kb)
ESM 1 (DOC 255 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Epidemiology and Health StatisticsSchool of Public Health of Qingdao UniversityQingdaoPeople’s Republic of China
  2. 2.Jiangsu Institute of Planning Parenthood ResearchNanjingPeople’s Republic of China
  3. 3.Department of Chronic Non-communicable DiseasesQingdao Municipal Centers for Diseases Control and PreventionQingdaoChina

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