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Impact of Prenatal and Postnatal Treatment of Sodium Fluoride and Aluminum Chloride on Some Hormonal and Sensorimotor Aspects in Rats

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A Correction to this article was published on 21 April 2018

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Abstract

In most communities, there is a constant exposure to environmental pollutants with probable negative impact on the development of the nervous system. Among these pollutants are the sodium fluoride (NaF) and aluminum chloride (AlCl3) which may represent a real threat to the proper functioning of the brain. This study comprises two fundamentally different strategies; in the first one, pregnant rats were administered a daily dose of NaF (0.15 g /L) or AlCl3 (500 mg/L) in the drinking water either separately or in combination with each other from day 6 of gestation until just after weaning. In the second approach, the male rats born to mothers exposed to the pollutants were divided into two groups. In the first, rats were continued to be treated with the same pollutants administered to them in the drinking water at the same dose level until the age of 70 days. The rats of the second group were supplied with drinking water without either one of the pollutants for a similar period of time. The rats exposed to NaF separately or in combination with AlCl3 during the prenatal life and subsequently through the postnatal stages exhibited disturbance in the locomotor activities. This was concomitant with alterations in plasma, PTH, ACTH, and estradiol levels. Additionally, the serum levels of LH and testosterone were altered in the two groups treated with sodium fluoride during the prenatal and up to the weaning periods or in the group which continued to have the NaF until day 70 after birth.

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Change history

  • 21 April 2018

    The original version of this article contained a mistake: The author name Ahood A. Al-Eidan was incorrectly written as Ahoud A. Al-Eidan.

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Author information

Authors and Affiliations

  1. Biology Department, Faculty of Science and Psychology Department, Taif University, Ta’if, Postal Code 5700, Kingdom of Saudi Arabia

    Amal A. Kinawy

  2. Cairo University, Giza, Postal Code 12613, Egypt

    Amal A. Kinawy

  3. Biology Department, Faculty of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 838, Dammam, Postal Code 31113, Saudi Arabia

    Ahood A. Al-Eidan

Authors
  1. Amal A. Kinawy
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  2. Ahood A. Al-Eidan
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Corresponding author

Correspondence to Amal A. Kinawy.

Additional information

The original version of this article was revised: The author name Ahood A. Al-Eidan was incorrectly written as Ahoud A. Al-Eidan.

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Kinawy, A.A., Al-Eidan, A.A. Impact of Prenatal and Postnatal Treatment of Sodium Fluoride and Aluminum Chloride on Some Hormonal and Sensorimotor Aspects in Rats. Biol Trace Elem Res 186, 441–448 (2018). https://doi.org/10.1007/s12011-018-1311-4

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  • DOI: https://doi.org/10.1007/s12011-018-1311-4

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