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Serum Concentrations of 15 Elements Among Helicobacter Pylori-Infected Residents from Lujiang County with High Gastric Cancer Risk in Eastern China

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Abstract

Helicobacter pylori (H. pylori) infection can interfere with the absorption of most elements, and the variations of some element levels are related to the incidence of gastric cancer. However, there have been conflicting results concerning the influence of H. pylori infection on serum element levels. The present study aimed to compare the serum element concentrations of H. pylori-infected local residents with uninfected residents from Lujiang County with high gastric cancer risk in Eastern China. We used data and serum samples from the H. pylori screening-survey program which was a cross-sectional study. We took 155 samples randomly from the screening survey, identified 74 H. pylori-positive residents and 81 H. pylori-negative residents by a serological test. The serum concentrations of 15 elements (calcium, magnesium, iron, zinc, selenium, copper, molybdenum, chromium, cobalt, nickel, lead, cadmium, mercury, arsenic, and aluminum) were determined using inductively coupled plasma mass spectrometry. Serum cobalt was found at higher levels in the H. pylori-infected residents than the H. pylori-uninfected residents (0.246 vs 0.205 μg/L, P = 0.022), but no statistically significant differences in the serum levels of other elements were found. This is the first study to report the serum concentrations of 15 elements and their relationships with the infection status of H. pylori among local residents from Lujiang County with high gastric cancer risk. Although the International Agency for Research on Cancer has classified cobalt and other soluble cobalt salts as possibly carcinogenic to human beings, our results may provide a clue to the relationships between cobalt, H. pylori, and gastric cancer.

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Funding

This study was funded by the National Natural Science Foundation of China (No. 81502806) and Grant for Scientific Research of BSKY from Anhui Medical University (No. XJ201523).

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui Province, 230032, China

    Anla Hu, Li Li, Chuanlai Hu, Chen Wang, Yan Jiang, Meng Zhang, Wenjun Chen, Qingli Bo & Qihong Zhao

  2. Department of Gastroenterology, Lujiang County People’s Hospital, Hefei, Anhui Province, 231500, China

    Daoming Zhang

  3. Department of Hygiene Analysis and Detection, School of Public Health, Anhui Medical University, Hefei, Anhui Province, 230032, China

    Chunmei Liang

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  1. Anla Hu
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  2. Li Li
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  3. Chuanlai Hu
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  4. Daoming Zhang
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  5. Chen Wang
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  6. Yan Jiang
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  10. Qingli Bo
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  11. Qihong Zhao
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Corresponding author

Correspondence to Qihong Zhao.

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This study received ethical approval from the Ethics Institutional Review Board from the Anhui Medical University. Written informed consents were obtained from all participants before taking part in the study.

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Hu, A., Li, L., Hu, C. et al. Serum Concentrations of 15 Elements Among Helicobacter Pylori-Infected Residents from Lujiang County with High Gastric Cancer Risk in Eastern China. Biol Trace Elem Res 186, 21–30 (2018). https://doi.org/10.1007/s12011-018-1283-4

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