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High Concentration of Fluoride Can Be Increased Risk of Abortion

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Abstract

The presence of fluoride in drinking water can be either beneficial or harmful for human health, depending on its concentration. Most adverse effects of fluoride are observed at high concentrations (above 1.5 mg/L). This study was aimed to evaluate the effect of fluoride concentrations in drinking water on spontaneous abortion in two regions: one with low fluoride concentration and another with high fluoride concentration. The results showed that there is a relationship between the concentration of fluoride in drinking water and abortion, so that the risk of abortion increased at high concentrations of fluoride. However, further studies are needed to clarify this relationship due to the small area and population in this study.

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References

  1. Peckham S, Awofeso N (2014) Water fluoridation: a critical review of the physiological effects of ingested fluoride as a public health intervention. Sci World J 2014:1–10. https://doi.org/10.1155/2014/293019

  2. Rahmani A, Rahmani K, Dobaradaran S, Mahvi AH, Mohamadjani R, Rahmani H (2010) Child dental caries in relation to fluoride and some inorganic constituents in drinking water in Arsanjan, Iran. Res Rep Fluoride 43(3):179–186

    CAS  Google Scholar 

  3. Dobaradaran S, Fazelini F, Mahvi AH, Hosseini SS (2009) Particulate airborne fluoride from an aluminium production plant in Arak, Iran. Res Rep Fluoride 42(3):228–232

    CAS  Google Scholar 

  4. Dhar V, Bhatnagar M (2009) Physiology and toxicity of fluoride. Indian J Dent Res 20(3):350–355. https://doi.org/10.4103/0970-9290.57379

    Article  PubMed  Google Scholar 

  5. Erdal S, Buchanan SN (2005) A quantitative look at fluorosis, fluoride exposure, and intake in children using a health risk assessment approach. Environ Health Perspect 113(1):111–117

    Article  PubMed  CAS  Google Scholar 

  6. Levy SM, Kohout FJ, Kiritsy MC, Heilman JR, Wefel JS (1995) Infants’ fluoride ingestion from water, supplements and dentifrice. J Am Dent Assoc 126(12):1625–1632. https://doi.org/10.14219/jada.archive.1995.0110

    Article  PubMed  CAS  Google Scholar 

  7. Marshall TA, Levy SM, Warren JJ, Broffitt B, Eichenberger-Gilmore JM, Stumbo PJ (2004) Associations between intakes of fluoride from beverages during infancy and dental fluorosis of primary teeth. J Am Coll Nutr 23(2):108–116. https://doi.org/10.1080/07315724.2004.10719350

    Article  PubMed  Google Scholar 

  8. Barbier O, Arreola-Mendoza L, Del Razo LM (2010) Molecular mechanisms of fluoride toxicity. Chem Biol Interact 188(2):319–333. https://doi.org/10.1016/j.cbi.2010.07.011

    Article  PubMed  CAS  Google Scholar 

  9. Grandjean P, Olsen JH (2004) Extended follow-up of cancer incidence in fluoride-exposed workers. J Natl Cancer Inst 96(10):802–803. https://doi.org/10.1093/jnci/djh155

    Article  PubMed  Google Scholar 

  10. Tohyama E (1996) Relationship between fluoride concentration in drinking water and mortality rate from uterine cancer in Okinawa prefecture, Japan. J Epidemiol 6(4):184–191. https://doi.org/10.2188/jea.6.184

    Article  PubMed  CAS  Google Scholar 

  11. Bassin EB, Wypij D, Davis RB, Mittleman MA (2006) Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer Causes Control 17(4):421–428. https://doi.org/10.1007/s10552-005-0500-6

    Article  PubMed  Google Scholar 

  12. Mohammadi AA, Yousefi M, Yaseri M, Jalilzadeh M, Mahvi AH (2017) Skeletal fluorosis in relation to drinking water in rural areas of West Azerbaijan, Iran. Sci Rep 7(1):17300. https://doi.org/10.1038/s41598-017-17328-8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Mohammadi AA, Yousefi M, Mahvi AH (2017) Fluoride concentration level in rural area in Poldasht city and daily fluoride intake based on drinking water consumption with temperature. Data Brief 13:312–315. https://doi.org/10.1016/j.dib.2017.05.045

    Article  PubMed  PubMed Central  Google Scholar 

  14. Amouei A, Mahvi A, Mohammadi A, Asgharnia H, Fallah S, Khafajeh A (2012) Fluoride concentration in potable groundwater in rural areas of Khaf city, Razavi Khorasan province, Northeastern Iran. Int J Occup Environ Med 3(4):201–203

    PubMed  CAS  Google Scholar 

  15. Zazouli MA, Mahvi AH, Dobaradaran S, Barafrashtehpour M, Mahdavi Y, Balarak D (2014) Adsorption of fluoride from aqueous solution by modified Azolla filiculoides. Fluoride 47(4):349–358

    CAS  Google Scholar 

  16. Asghari FB, Mohammadi AA, Aboosaedi Z, Yaseri M, Yousefi M (2017) Data on fluoride concentration levels in cold and warm season in rural area of Shout (West Azerbaijan, Iran). Data Brief 15:312–315

    Google Scholar 

  17. Faraji H, Mohammadi AA, Akbari-Adergani B, Saatloo NV, Lashkarboloki G, Mahvi AH (2014) Correlation between fluoride in drinking water and its levels in breast milk in Golestan Province, northern Iran. Iran J Public Health 43(12):1664–1668

    PubMed  PubMed Central  Google Scholar 

  18. Yousefi M, Mohammadi AA, Yaseri M, Mahvi AH (2017) Epidemiology of fluoride and its contribution to fertility, infertility, and abortion: an ecological study in West Azerbaijan Province, Poldasht County, Iran. Res Rep Fluoride 50(3):343–353

    Google Scholar 

  19. Aghaei M, Derakhshani R, Raoof M, Dehghani M, Mahvi AH (2015) Effect of fluoride in drinking water on birth height and weight: an ecological study in Kerman Province, Zarand County, Iran. Fluoride 48:160–168

    CAS  Google Scholar 

  20. Ngo TD, Keogh S, Nguyen TH, Le HT, Pham KH, Nguyen YB (2014) Risk factors for repeat abortion and implications for addressing unintended pregnancy in Vietnam. Int J Gynecol Obstet 125(3):241–246. https://doi.org/10.1016/j.ijgo.2013.11.014

    Article  Google Scholar 

  21. Hooker AB, Lemmers M, Thurkow AL, Heymans MW, Opmeer BC, Brölmann HA, Mol BW, Huirne JA (2013) Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome. Hum Reprod Update 20(2):262–278. https://doi.org/10.1093/humupd/dmt045

    Article  PubMed  CAS  Google Scholar 

  22. Eaton ADScaEWR (2005) Standard Methods for the Examination of water waster: AWWA

  23. Sun Z, Niu R, Wang B, Wang J (2014) Altered sperm chromatin structure in mice exposed to sodium fluoride through drinking water. Environ Toxicol 29(6):690–696. https://doi.org/10.1002/tox.21796

    Article  PubMed  CAS  Google Scholar 

  24. Choubisa S (2013) Fluorotoxicosis in diverse species of domestic animals inhabiting areas with high fluoride in drinking water of Rajasthan, India. Proc Natl Acad Sci India Sect B: Biol Sci 83(3):317–321. https://doi.org/10.1007/s40011-012-0138-6

    Article  CAS  Google Scholar 

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Acknowledgements

The authors want to thank authorities of the Neyshabur University of Medical Sciences for their comprehensive support for this study.

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Authors and Affiliations

  1. Department of Environmental Health Engineering, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Vahid Kazemi Moghaddam & Ali Akbar Mohammadi

  2. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Science, Tehran, Iran

    Mahmood Yousefi, Amir Hossein Mahvi & Mostafa Hadei

  3. Students Research Committee, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Mahmood Yousefi & Zahrasadat Robati

  4. Department of Environmental Health Engineering, School of Public Health, Birjand University of Medical Science, Birjand, Iran

    Ahmad Khosravi

  5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Mehdi Yaseri

  6. Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran

    Amir Hossein Mahvi

  7. Department of Environmental Health Engineering, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran

    Adel Mokammel

Authors
  1. Vahid Kazemi Moghaddam
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  2. Mahmood Yousefi
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  3. Ahmad Khosravi
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  4. Mehdi Yaseri
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  5. Amir Hossein Mahvi
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  6. Mostafa Hadei
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  7. Ali Akbar Mohammadi
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  8. Zahrasadat Robati
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  9. Adel Mokammel
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Correspondence to Ali Akbar Mohammadi.

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Moghaddam, V.K., Yousefi, M., Khosravi, A. et al. High Concentration of Fluoride Can Be Increased Risk of Abortion. Biol Trace Elem Res 185, 262–265 (2018). https://doi.org/10.1007/s12011-018-1250-0

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  • DOI: https://doi.org/10.1007/s12011-018-1250-0

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