Subchronic Arsenic Exposure Through Drinking Water Alters Lipid Profile and Electrolyte Status in Rats
Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. On the 91st day, rats were sacrificed and blood was collected. Lipid profile and the levels of electrolytes (sodium, potassium, and chloride) were assessed in plasma. Arsenic reduced high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio, but increased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and electrolytes. The results suggest that the arsenic-mediated dyslipidemia and electrolyte retention could be important mechanisms in the arsenic-induced vascular disorder.
KeywordsArsenic Lipid profile Aorta Rats
The authors are grateful to the Department of Biotechnology (DBT), New Delhi, India, for providing financial support in conducting the study. The fellowship awarded to the first author by the Institute is gratefully acknowledged. The authors are also thankful to the Director, Indian Veterinary Research Institute, for providing necessary facilities.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
- 1.Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Van Geen A, Graziano J, Ahsan H (2010) Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet 376:252–258CrossRefPubMedPubMedCentralGoogle Scholar
- 4.WHO (2010) Exposure to arsenic: a major public health concern Geneva: WHO Press. Available: http://www.who.int/ipcs/assessment/ public health/arsenic/en/. Accessed on 23 Oct 2013
- 7.Guha Mazumder D, Dasgupta UB (2011) Chronic arsenic toxicity: studies in West Bengal, India. Kaohsiung. J Med Sci 27:360–370Google Scholar
- 9.Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M, Graziano JH, Ahsan H (2009) Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the health effects of arsenic longitudinal study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 239:184–192CrossRefPubMedPubMedCentralGoogle Scholar
- 11.Michel T, Hoffman BB (2012) Treatment of myocardial ischemia and hypertension. In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. In: Brunton LL, Chabner BA, Knollmann BC (eds) 12th edn. The Mc Graw Hill Company, pp 765–766Google Scholar
- 21.Burtis CA, Ashwood CR, Burns DE (2006) Textbook of clinical chemistry and molecular diagnostics, 4th edn. Saunders, New DelhiGoogle Scholar
- 22.Guyton AC, Hall JE (2006) Textbook of medical physiology, 11th edn. W. B. Saunders, Philadelphia, pp. 365–381Google Scholar