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Selenium Status in Patients with Turner Syndrome: a Biochemical Assessment Related with Body Composition

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Abstract

Studies about selenium status in patients with Turner syndrome (TS) are non-existent in the literature. The aim of this study was to evaluate selenium status in patients with TS, while considering the different ages of the studied population and the relation with body composition. In total, 33 patients with TS were evaluated and grouped according to their developmental stages (children, adolescents, and adults). Selenium concentrations in their plasma, erythrocytes, urine, and nails were determined by using hydride generation atomic absorption spectrometry and erythrocyte glutathione peroxidase activity were measured by using Randox commercial kits. Additionally, height, weight, body fat percentage, waist circumference, and waist-height ratio were measured to characterize the patients. No differences in the selenium concentrations in the plasma, erythrocyte, urine, and nails or in the glutathione peroxidase activity were observed among the age groups (p > 0.05). The evaluated selenium levels were less than the established normal ones. The patients with larger waist circumference, body fat percentage, body mass index, and waist-height ratio showed lower glutathione peroxidase enzyme activity (p = 0.023). The present study shows that most patients with TS are deficient in selenium and that those with a greater accumulation of body fat have a lower GPx activity.

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References

  1. Nielsen J, Wohlert M (1990) Sex chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Birth Defects Orig Artic Ser 26:209–223

    CAS  PubMed  Google Scholar 

  2. Davenport ML (2010) Approach to the patient with turner syndrome. J Clin Endocrinol Metab 95:1487–1495

    Article  CAS  PubMed  Google Scholar 

  3. Zhong Q, Layman LC (2012) Genetic considerations in the patient with Turner syndrome—45,X with or without mosaicism. Fertil Steril 98:775–779

    Article  PubMed  PubMed Central  Google Scholar 

  4. Massa GG, Vanderschueren-Lodeweyckx M (1991) Age and height at diagnosis in Turner syndrome: influence of paternal height. Pediatrics 88:1148–1152

    CAS  PubMed  Google Scholar 

  5. Pasquino AM, Passeri F, Pucarelli I, Segni M, Municchi G (1997) Spontaneous pubertal development in Turner’s syndrome. Italian study group for Turner’s syndrome. J Clin Endocrinol Metab 82:1810–1813

    CAS  PubMed  Google Scholar 

  6. Rayman MP (2012) Selenium and human health. Lancet 379:1256–1268

    Article  CAS  PubMed  Google Scholar 

  7. Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease. Antioxid Redox Signal 14:1337–1383

    Article  CAS  PubMed  Google Scholar 

  8. Mangiapane E, Pessione A, Pessione E (2014) Selenium and selenoproteins: an overview on different biological systems. Curr Protein Pept Sci 24:598–607

    Article  Google Scholar 

  9. Kohrle J (2013) Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes 20:441–448

    Article  PubMed  Google Scholar 

  10. Ryan-Harshman M, Aldoori W (2005) The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Canadian J Diet Practice Res 66:98–102

    Article  Google Scholar 

  11. Suzuki KT, Ogra Y (2002) Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with use of enriched Se. Food Addit Contam 19:974–983

    Article  CAS  PubMed  Google Scholar 

  12. Diplock AT (1993) Indexes of selenium status in human populations. Am J Clin Nutr 57:256S–258S

    CAS  PubMed  Google Scholar 

  13. Campbell D, Bunker VW, Thomas AJ, Clayton BE (1989) Selenium and vitamin E status of healthy and institutionalized elderly subjects: analysis of plasma, erythrocytes and platelets. Br J Nutr 62:221–227

    Article  CAS  PubMed  Google Scholar 

  14. Arnaud J, Bertrais S, Roussel AM, Arnault N, Ruffieux D, Favier A, et al. (2006) Serum selenium determinants in French adults: the SU.VI.M.AX study. Br J Nutr 95:313–320

    Article  CAS  PubMed  Google Scholar 

  15. Kimmons JE, Blanck HM, Tohill BC, Zhang J, Khan LK (2006) Associations between body mass index and the prevalence of low micronutrient levels among US adults. Med Gen Med 8:59

    Google Scholar 

  16. Spina A, Guallar E, Rayman MP, Tigbe W, Kandala N-B, Stranges S (2013) Anthropometric indices and selenium status in British adults: the U.K. National Diet and Nutrition Survey. Free Radic Biol Med 65:1315–1321

    Article  CAS  PubMed  Google Scholar 

  17. Gravholt CH (2004) Epidemiological, endocrine and metabolic features in Turner syndrome. Eur J Endocrinol 151:657–687

    Article  CAS  PubMed  Google Scholar 

  18. Karlberg J, Albertsson-Wikland K, Naeraa RW, Rongen-Westerlaken C (1993) Reference values for spontaneous growth in Turner girls and its use in estimating treatment effects. In: Hibi I, Takano K (eds) Basic and clinical approach to Turner syndrome. Excerpta Medica, Amsterdam, pp. 77–82

    Google Scholar 

  19. Kuczmarski RJ, Ogden CL, Guo SS, et al. (2002) 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 246:1–190

    Google Scholar 

  20. World Health Organization (2000) Consultation on obesity. Obesity: preventing and managing the global epidemic. WHO Technical Report Series 894, Geneva

    Google Scholar 

  21. Savva SC, Tornaritis M, Savva ME, et al. (2000) Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index. Int J Obes 24:1453–1458

    Article  CAS  Google Scholar 

  22. Ashwell M, Gunn P, Gibson S (2012) Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev 13:275–286

    Article  CAS  PubMed  Google Scholar 

  23. Biodynamics (1995) Monitor de composição corporal: biodynamics modelo 310, Biodynamics

  24. Hao D-Q, Xie G-H, Zhang Y-M, Tian G-J (1996) Determination of serum selenium by hydride generation flame atomic absorption spectrometry. Talanta 43:595–600

    Article  CAS  PubMed  Google Scholar 

  25. Sabé AR, Rubio A, García-Beltrán L (2000) Determination of selenium in human blood specimens by electrothermal atomic absorption. Anal Chim Acta 419:121–135

    Article  Google Scholar 

  26. Romero DC, Blanco LF, Sánchez PH, Rodríguez E, Majem LS (2001) Serum selenium concentration in a representative sample of the Canarian population. Sci Total Environ 269:65–73

    Article  CAS  Google Scholar 

  27. Van Dael P, Deelstra H (1993) Selenium. Int J Vitam Nutr Res 63:312–316

    CAS  PubMed  Google Scholar 

  28. Yang GQ, Wang SZ, Zhou RH, Sun SZ (1983) Endemic selenium intoxication of humans in China. Am J Clin Nutr 37:872–881

    CAS  PubMed  Google Scholar 

  29. Alfthan G, Bogye G, Aro A, Feher J (1992) The human selenium status in Hungary. J Trace Elem Electrolytes Health Dis 6:233–238

    CAS  PubMed  Google Scholar 

  30. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158–169

    CAS  PubMed  Google Scholar 

  31. Baldin AD, Fabbri T, Siviero-Miachon AA, et al. (2011) Growth hormone effect on body composition in turner syndrome. Endocrine 40:486–491

    Article  CAS  PubMed  Google Scholar 

  32. Fonteles AVR, Dondoni RS, Boguszewski MCS, et al. (2011) Estatura final (EF) em síndrome de Turner (ST): experiência de 76 casos acompanhados na Unidade de Endocrinologia Pediátrica do Hospital de Clínicas da Universidade Federal do Paraná. Arq Bras Endocrinol Metab 55:318–325

    Article  Google Scholar 

  33. Stefanowicz FA, Talwar D, O’Reilly DSJ, et al. (2013) Erythrocyte selenium concentration as a marker of selenium status. Clin Nutr 32:837–842

    Article  CAS  PubMed  Google Scholar 

  34. Institute of Medicine (2000) Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academies Press, Washington

    Google Scholar 

  35. Fox T, Fairweather-Tait SJ (1999) Selenium. In: Hurrell R (ed) The mineral fortification of foods, 2nd edn. Leatherhead Publishing, Surrey, pp. 1–44

    Google Scholar 

  36. Gibson RS (2005) Assessment of iodine and selenium status. In: Gibson RS (ed) Principles of nutritional assessment, 2nd edn. Oxford University Press, Nova York, pp. 749–796

    Google Scholar 

  37. Satia JA, King IB, Morris JS, Stratton K, White E (2006) Toenail and plasma levels as biomarkers of selenium exposure. Ann Epidemiol 16:53–58

    Article  PubMed  Google Scholar 

  38. Martens IBG, Cardoso BR, Hare DJ, et al. (2015) Selenium status in preschool children receiving a Brazil nut–enriched diet. Nutrition 31:1339–1343

    Article  CAS  PubMed  Google Scholar 

  39. Gaeta LM, Tozzi G, Pastore A, Federici G, Bertini E, Piemonte F (2002) Determination of superoxide dismutase and glutathione peroxidase activities in blood of healthy pediatric subjects. Clin Chim Acta 322:117–120

    Article  CAS  PubMed  Google Scholar 

  40. Muntau AC, Streiter M, Kappler M, et al. (2002) Age-related reference values for serum selenium concentrations in infants and children. Clin Chem 48:555–560

    CAS  PubMed  Google Scholar 

  41. Hincal F, Basaran N, Yetgin S, Gokmen O (1994) Selenium status in Turkey: II. Serum selenium concentration in healthy residents of different ages in Ankara. J Trace Elem Electrolytes Health Dis 8:9–12

    CAS  PubMed  Google Scholar 

  42. Ortega RM, Rodríguez-Rodríguez E, Aparicio A, et al. (2012) Young children with excess of weight show an impaired selenium status. Int J Vitam Nutr Res 82:121–129

    Article  CAS  PubMed  Google Scholar 

  43. González S, Huerta JM, Fernández S, Patterson DM, Lasheras C (2006) Food intake and serum selenium concentration in elderly people. Annu Nutr Metab 50:126–131

    Article  Google Scholar 

  44. Wang Y, Gao X, Pedram P, et al. (2016) Significant beneficial Association of High Dietary Selenium Intake with reduced body fat in the CODING study. Nutrients. doi:10.3390/nu8010024

    Google Scholar 

  45. Trevisan M, Browne R, Ram M, et al. (2001) Correlates of markers of oxidative status in the general population. Am J Epidemiol 154:348–356

    Article  CAS  PubMed  Google Scholar 

  46. Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, et al. (2011) Inflammation, oxidative stress, and obesity. Int J Mol Sci 12:3117–3132

    Article  PubMed  PubMed Central  Google Scholar 

  47. Galili O, Versari D, Sattler KJ, et al. (2007) Early experimental obesity is associated with coronary endotelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol 292:H904–H911

    Article  CAS  PubMed  Google Scholar 

  48. Al-Daghri NM, Al-Attas OS, Alokail MS, et al. (2013) Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances. Eur J Clin Investig 43:183–189

    Article  CAS  Google Scholar 

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Acknowledgments

We acknowledge the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP/N° 2007/53865-8) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/N° 130252/2006-9) for their financial support for this research, and the patients who made this research possible.

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Authors and Affiliations

  1. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, n°580, Cidade Universitária, São Paulo, SP, 05508-900, Brazil

    Liliane Viana Pires, José Alexandre Coelho Pimentel, Luciana Sigueta Nishimura & Silvia Maria Franciscato Cozzolino

  2. Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil

    Adriana Aparecida Siviero-Miachon & Angela Maria Spinola-Castro

  3. Department of Nutrition, State University of Ceara, Ceara, Brazil

    Carla Soraya Costa Maia

Authors
  1. Liliane Viana Pires
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  2. Adriana Aparecida Siviero-Miachon
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  3. Angela Maria Spinola-Castro
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  4. José Alexandre Coelho Pimentel
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  5. Luciana Sigueta Nishimura
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  6. Carla Soraya Costa Maia
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  7. Silvia Maria Franciscato Cozzolino
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Correspondence to Liliane Viana Pires.

Ethics declarations

This study was conducted according to the guidelines established by the Declaration of Helsinki, and all the procedures involving human subjects/patients were approved by the Ethics Committee of the Faculty of Pharmaceutical Sciences of the University of São Paulo (EC # 128/2006). Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflicts of interest.

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Pires, L.V., Siviero-Miachon, A.A., Spinola-Castro, A.M. et al. Selenium Status in Patients with Turner Syndrome: a Biochemical Assessment Related with Body Composition. Biol Trace Elem Res 176, 217–224 (2017). https://doi.org/10.1007/s12011-016-0831-z

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  • DOI: https://doi.org/10.1007/s12011-016-0831-z

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