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Evaluation of the Relationship Between Height and Zinc, Copper, Iron, Calcium, and Magnesium Levels in Healthy Young Children in Beijing, China

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Abstract

We evaluated the relationship between child (aged 6–36 months) height and blood zinc, copper, iron, calcium, and magnesium concentrations. We selected 840 children following a physical examination. Weight and supine length or standing height were measured according to the World Health Organization guidelines. Polarographic analysis was used to measure zinc, copper, iron, magnesium, and calcium levels. Differences in heights between groups with low vs. high mineral concentrations, stratified by sex and age, were compared by analysis of variance. Relationships between these five elements and heights were tested by multiple regression analysis. Zinc levels in the shorter group (height for age (HAZ) ≤ −0.3) were 135.84 ± 39.76 and 134.83 ± 37.57 μmol/L in boys and girls, respectively. Zinc concentrations in the taller group (HAZ > −0.3) were 142.50 ± 35.85 and 140.52 ± 35.80 μmol/L in boys and girls, respectively. The difference between the two height groups in boys and girls was statistically significant. Compared with those (143.06 ± 33.76 μmol/L) in the taller group, zinc concentration (131.30 ± 40.75 μmol/L) in the shorter group was significantly lower (p = 0.04) at age 6–12 months. Height was positively correlated with zinc level in children aged 6–12 months (p < 0.05). Zinc levels were positively correlated with calcium, magnesium, and iron concentrations in children aged 6–36 months (p < 0.05). Our results indicated that zinc levels and height are correlated, and zinc levels were related to calcium, magnesium, copper, and iron concentrations. Therefore, to ensure healthy development in children, blood levels of these five elements should be balanced.

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References

  1. Larkin EC, Rao CA (1990) Importance of fetal and neonatal iron: adequacy for normal development of central nervous system. In: Dobbing J (ed) Brain behaviour and iron in the infant diet. Springer, London, pp. 43–63

    Chapter  Google Scholar 

  2. Koolman J, Roehm KH (2005) Color atlas of biochemistry. Thieme, Marburg

    Google Scholar 

  3. Yamaguchi M, Gao YH, Ma ZJ (2000) Synergistic effect of genistein and zinc on bone components in the femoral-metaphyseal tissues of female rats. J Bone Miner Metab 18:77–83

    Article  CAS  PubMed  Google Scholar 

  4. Bouglé DL, Sabatier JP, Guaydier-Souquières G, Guillon-Metz F, Laroche D, Jauzac P, Bureau F (2004) Zinc status and bone mineralisation in adolescent girls. J Trace Elements Med Biol 18:17–21

    Article  Google Scholar 

  5. Reginster JY, Strause LG, Saltman O, Franchimont P (1988) Trace elements and postmenopausal osteoporosis: a preliminary study of decreased serum manganese. Med Sci Res 16:337–338

    CAS  Google Scholar 

  6. Ma ZJ, Yamaguchi M (2001) Role of endogenous zinc in the enhancement of bone protein synthesis associated with bone growth of newborn rats. J Bone Miner Metab 19:38–44

    Article  CAS  PubMed  Google Scholar 

  7. Beattie JH, Avenell A (1992) Trace element nutrition and bone metabolism. Nutr Res Re 5:167–188

    Article  CAS  Google Scholar 

  8. Medeiros DM, Plattner A, Jennings D, Stoecker B (2002) Bone morphology, strength and density are compromised in iron-deficient rats and exacerbated by calcium restriction. J Nutr 132:3135–3141

    CAS  PubMed  Google Scholar 

  9. Ye J, Du C, Wang L, Li Z, Huang S, Wang H, He L, Bi Y, Wang C (2015) Relationship of blood levels of Pb with Cu, Zn, Ca, Mg, Fe, and Hb in children aged 0 approximately 6 years from Wuhan, China. Biol Trace Elem Res 164:18–24

    Article  CAS  PubMed  Google Scholar 

  10. Hu JF, Zhao XH, Jia JB, Parpia B, Campbell TC (1993) Dietary calcium and bone density among middle-aged and elderly women in China. Am J Clin Nutr 58:219–227

    CAS  PubMed  Google Scholar 

  11. Matkovic V, Ilich JZ (1993) Calcium requirements for growth: are current recommendations adequate? Nutr Rev 51:171–180

    Article  CAS  PubMed  Google Scholar 

  12. Singh P, Toteja GS (2003) Micronutrient profile of Indian children and women: summary of available data from iron and vitamin a. Indian Pediatr 40:477–479

    PubMed  Google Scholar 

  13. Lee WT, Leung SS, Leung DM, Tsang HS, Lau J, Cheng JC (1995) Randomized double-blind controlled calcium supplementation trial, and bone and height acquisition in children. Br J Nutr 74:125–139

    Article  CAS  PubMed  Google Scholar 

  14. Winzenberg T, Shaw K, Fryer J, Jones G (2007) Calcium supplements in healthy children do not affect weight gain, height, or body composition. Obesity (Silver Spring) 15:1789–1798

    Article  CAS  Google Scholar 

  15. Mason JB, Lotfi M, Dalmiya N, Sethuraman K, Deitchler M, Geibel S, Gillenwater K, Gillman A, Mason K, Mock N (2000) United Nations administrative committee on coordination subcommittee on nutrition: fourth report on the world nutrition situation. Switzerland, Geneva

    Google Scholar 

  16. Gibson RS (2000) Zinc supplementation for infants. Lancet 355:2008–2009

    Article  CAS  PubMed  Google Scholar 

  17. Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T (2011) Zinc homeostasis and signalling in health and diseases. J Biol Inorg Chem 16:1123–1134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Prasad AS (1995) Zinc: an overview. Nutrition 11:93–99

    CAS  PubMed  Google Scholar 

  19. Lianhe XG (2010) Analysis of trace elements of children aged from 0 to 7 years old in Hanzhong China. Stud Trace Elem Health 27:3–4

    Google Scholar 

  20. Knerr I, Blessing H, Seyferth S, Watling RJ, Chaudhri MA (2013) Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis. Ann Nutr Metab 63:168–173

    Article  CAS  PubMed  Google Scholar 

  21. Taneja S, Strand T, Sommerfelt H, Bahl R, Bhandari N (2010) Zinc supplementation for four months does not affect growth in young north Indian children. J Nutr 140:630–634

    Article  CAS  PubMed  Google Scholar 

  22. Cao J, Gao Z, Yan J, Li M, Su J, Xu J,Yan CH (2015) Evaluation of trace elements and their relationship with growth and development of young children. Biol Trace Elem Res DOI:0.1007/s12011–015–0537-7.

  23. Sungthong R, Mo-Suwan L, Chongsuvivatwong V, Geater AF (2002) Once weekly is superior to daily iron supplementation on height gain but not on hematological improvement among schoolchildren in Thailand. J Nutr 132:418–422

    CAS  PubMed  Google Scholar 

  24. Jabbari H, Bakhshian F, Asgari M, Sattari M, Naghavi-Behzad M, Mashayekhi SO (2013) Antenatal micronutrient supplementation relationship with children's weight and height from birth up to the age of 18 months Iranian. Iran J Public Health 42:626–634

    PubMed  PubMed Central  Google Scholar 

  25. Kanani SJ, Poojara RH (2000) Supplementation with iron and folic acid enhances growth in adolescent Indian girls. J Nutr 130:452S–455S

    CAS  PubMed  Google Scholar 

  26. Ralph A,Arthur J,Garrow JS,James PT, Ralph A (2000) Iron, zinc and other trace elements.In: Human nutrition and dietetics, 10th edn. Churchill Livingstone, New York.

  27. Soetan KO, Olaiya CO, Oyewole OE (2010) The importance of mineral elements for humans, domestic animals and plants. Afr J Food Sci 4:200–222

    CAS  Google Scholar 

  28. Duley L, Henderson-Smart DJ, Walker JA, Chou D (2010) Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev 12:CD000127. doi:10.1002/14651858.CD000127.pub2

    Google Scholar 

  29. Angelova MG, Petkova-Marinova TV, Pogorielov MV, Loboda AN, Nedkova-Kolarova VN, Bozhinova AN (2014) Trace element status (iron, zinc, copper, chromium, cobalt, and nickel) in iron-deficiency anaemia of children under 3 years. Anemia 2014:718089. doi:10.1155/2014/718089

    Article  PubMed  PubMed Central  Google Scholar 

  30. Suárez-Ortegón MF, Jiménez P, Mosquera M, Pradilla AG, Gracia AB, Aguilar C (2011) Inverse correlation between serum calcium and copper levels in male urban Colombian preschool children: relationships with an thropometry and age. Biol Trace Elem Res 144:445–453

    Article  PubMed  Google Scholar 

  31. Lin CN, Wilson A, Church BB, Ehman S, Roberts WL, McMillin GA (2012) Pediatric reference intervals for serum copper and zinc. Clin Chim Acta 413(5–6):612–615

    Article  CAS  PubMed  Google Scholar 

  32. Farzin L, Moassesi ME, Sajadi F, Amiri M, Shams H (2009) Serum levels of antioxidants (Zn, Cu, Se) in healthy volunteers living in Tehran. Biol Trace Elem Res 129:36–45

    Article  CAS  PubMed  Google Scholar 

  33. Rukgauer M, Klein J, Kruse-Jarres JD (1997) Reference values for the trace elements copper, manganese, selenium, and zinc in the serum/plasma of children, adolescents, and adults. J Trace Elem Med Biol 11:92–98

    Article  CAS  PubMed  Google Scholar 

  34. Ridefelt P, Aldrimer M, Rodoo P, Niklasson F, Jansson L, Gustafsson J (2011) Reference intervals for phosphate, magnesium and calcium in healthy Swedish children. Clin Biochem 44:542–543

    Article  Google Scholar 

  35. Marwaha RK, Khadgawat R, Tandon N, Kanwar R, Narang A, Sastry A, Bhadra K, Kalaivani M (2010) Reference intervals of serum calcium, ionized calcium, phosphate and alkaline phosphatase in healthy Indian school children and adolescents. Clin Biochem 43:1217–1219

    Google Scholar 

  36. Lockltch G, Halsteed AC, Alberahelm S, Maccallum C, Qulgley G (1988) Age- and sex specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer. Clin Chem 34:1622–1623

    Google Scholar 

  37. Liu J, Yuan E, Zhang Z, Jia L, Yin Z, Meng X, H D (2012) Sex-specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead, and cadmium in infants and children. Clin Biochem 45(6):416–419

    Article  CAS  PubMed  Google Scholar 

  38. Grandjean P, Nielsen GD, Jorgensen PJ, Horder M (1991) Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest 52:321–337

    Article  Google Scholar 

  39. Ece A, Uyanik BS, Iscan A, Ertan P, Yigitoglu MR (1997) Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia. Biol Trace Elem Res 59:31–39

    Article  CAS  PubMed  Google Scholar 

  40. Gleerup A, Rossander HL, Gramatkovski E, Hallberg L (1995) Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. Am J Clin Nutr 61:97–104

    CAS  PubMed  Google Scholar 

  41. Hempe JM, Cousins RJ (1990) Present knowledge in nutrition. In: Brown ML (ed) . ILSI Nutrition Foundation, Washington DC, pp. 251–280

    Google Scholar 

  42. Botash AS, Nasca J, Dubowy R, Weinberger HL, Oliphant M (1992) Zinc induced copper deficiency in an infant. Am J Dis Child 146:709–711

    CAS  PubMed  Google Scholar 

  43. De la Cruz-Góngora V, Gaona B, Villalpando S, Shamah-Levy T, Robledo R (2012) Anemia and iron, zinc, copper and magnesium deficiency in Mexican adolescents: National Health and nutrition survey 2006. Salud Publica Mex 54(2):135–145

    Article  PubMed  Google Scholar 

  44. Dashti-Khavidaki S, Khalili H, Vahedi SM, Lessan-Pezeshki M (2010) Serum zinc concentrations in patients on maintenance hemodialysis and its relationship with anemia, parathyroid hormoneconcentrations and pruritus severity. Saudi J Kidney Dis Transpl 21(4):641–645

    PubMed  Google Scholar 

  45. Hu J, Wang AF, Qi HX, Hong Z (2014) Effect of nutritional among children with rion deficiency anemia. Chinese Journal of Health Education 30(9):795–797

    Google Scholar 

  46. Yang YY,Liu LM,Yang WF,Zhang SP,Wang Y (2014) Research on serum vitamin A, iron and zinc status of infants aged 0-18 months and the relationship with Hb in rural area of Shaanxi province 22(7):690–692

Download references

Acknowledgments

The study was supported by the National Natural Science Foundation of China (grant number 81202219) of the People’s Republic of China.

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Authors and Affiliations

  1. Integrated Early Childhood Development, Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China

    Yan Yin, Ni Jia, Aihua Liu, Zangwen Tan, Qiong Wu, Zhaoyang Fan, Tao Li & Lijun Wang

  2. Tuanjiehu Community Health Service Center, Chaoyang District Tuanjiehu No. 7, Beijing, 100053, China

    Yongjin Li

  3. Environmental Standards Institute, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China

    Qin Li

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  1. Yan Yin
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Correspondence to Yan Yin.

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Yin, Y., Li, Y., Li, Q. et al. Evaluation of the Relationship Between Height and Zinc, Copper, Iron, Calcium, and Magnesium Levels in Healthy Young Children in Beijing, China. Biol Trace Elem Res 176, 244–250 (2017). https://doi.org/10.1007/s12011-016-0830-0

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