Biological Trace Element Research

, Volume 176, Issue 2, pp 321–327 | Cite as

Antidiabetic Activity of a Lotus Leaf Selenium (Se)-Polysaccharide in Rats with Gestational Diabetes Mellitus



A selenium (Se)-containing polysaccharide, lotus leaf selenium (Se)-polysaccharide (LLP), was isolated from a lotus leaf. The effects of LLP on antioxidant enzyme activities and insulin resistance in pregnant rats with gestational diabetes mellitus (GDM) were investigated. LLP administered orally at two doses (50 and 100 mg/kg) could significantly reverse the weight loss of pregnant rats before the delivery, fetal rats, and placentas in GDM rats (P < 0.05). Furthermore, LLP treatment induced a decrease of fasting blood glucose (FBG) and fasting blood insulin (FINS) levels in GDM rats, but an increase of hepatic glycogen content, when compared with those in GDM rats (P < 0.05). Also, oral administrations of LLP markedly improved the lipid profile of GDM rats, as evidenced by a reduction of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol levels except for the high-density lipoprotein (HDL) cholesterol level. Additionally, antioxidant enzyme levels, such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione (GSH), in liver tissues of the GDM group were lower than those of the other groups, and following treatment of LLP, these indexes in liver tissues were equivalent to those of the control group (P > 0.05). All the data indicated that LLP may be a promising drug candidate or a healthcare food for GDM therapy or protection.


Lotus leaf selenium (Se)-polysaccharide (LLP) Gestational diabetes mellitus Oxidative damage 


Compliance with Ethical Standards

All of the experimental procedures were conducted strictly in conformity with the NIH Guide for the Care and Use of Laboratory Animals and approved by the Animal Care Committee of Xinxiang Medical University.

Conflict of Interest

The authors declare that they have no competing interests.

Ethical Standard

All institutional and national guidelines for the care and use of laboratory animals were followed.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Nutritional DepartmentFirst Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  2. 2.Endocrinology DepartmentFirst Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  3. 3.Clinical LaboratoryFirst Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina

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