Biological Trace Element Research

, Volume 176, Issue 2, pp 338–341 | Cite as

Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency

  • Sevim Çiftçi Yegin
  • Semiha Dede
  • Leyla Mis
  • Fatmagül Yur


This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.


DNA damage Renal impair Zinc 


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflict of interest. All authors have read and approved the final manuscript.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Sevim Çiftçi Yegin
    • 1
  • Semiha Dede
    • 2
  • Leyla Mis
    • 3
  • Fatmagül Yur
    • 4
  1. 1.Health Service Vocational School of Higher EducationUniversity of GiresunGiresunTurkey
  2. 2.Faculty of Veterinary Science, Department of BiochemistryUniversity of Yüzüncü YılVanTurkey
  3. 3.Faculty of Veterinary Science, Department of PhysiologyUniversity of Yüzüncü YılVanTurkey
  4. 4.Fethiye School of Health, Department of Nutrition and DieteticsUniversity of Muğla Sıtkı KoçmanMuğlaTurkey

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