Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency
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This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.
KeywordsDNA damage Renal impair Zinc
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflict of interest. All authors have read and approved the final manuscript.
- 1.Arcasoy A (2002) Çinko ve Çinko Eksikliği. Talasemi Derneği Yayınları, Ankara (In Turkish)Google Scholar
- 2.Rotsan EF, De Buys HV, Madey DL (2002) Evidence supporting zinc as an important antioxidant for skin. Int J of Dermatol 4:606–611Google Scholar
- 3.Anonymous (2009) Genta 160 mg I. E. ULAGAY. http://www.ilacabak.com/ilacgoster.php?Id=3384 Accessed 18 July 2009
- 4.Şahin T, Çamkerten İ (2003) Kedi ve köpeklerin böbrek hastalıklarında antibiyotiklerin kullanımı. YYU Vet Fak Derg 14(1):82–86 In TurkishGoogle Scholar
- 7.Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 23:1939–1951Google Scholar