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Biological Trace Element Research

, Volume 176, Issue 2, pp 391–400 | Cite as

Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys

Article

Abstract

The ameliorative effects of selenium (Se) against cadmium (Cd)-induced toxicity have been reported extensively. However, few studies have assessed the effects of multiple ions simultaneously on the variations of elements. In this study, the changes in Se, Cd, and 26 other element concentrations were investigated in chicken kidneys. One hundred and twenty-eight 31-week-old laying hens were fed a diet supplemented with either Se, Cd, or both Se and Cd for 90 days. The ion content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). We found that the Se, Cd, and combined Se and Cd treatments significantly affected the trace elements in the chicken kidneys. The Cd supplement caused ion profile disorders, including reduced concentrations of V, Cr, Mn, Mo, As, Ba, Hg, Ti, and Pb and increased Si, Cu, Li, Cd, and Sb. The Se supplement reduced the contents of Co, Mo, and Pb and increased the contents of Cr, Fe, and Se. Moreover, Se also increased the concentrations of Cr, Mn, Zn, and Se and decreased those of Li and Pb, which in contrast were induced by Cd. Complex interactions between elements were analyzed, and both positive and negative correlations among these elements are presented. The present study indicated that Se can help against the negative effects of Cd and may be related to the homeostasis of the trace elements in chicken kidneys.

Keywords

Selenium Cadmium Laying hens Kidney Trace element 

Notes

Acknowledgments

This work was supported by the China Postdoctoral Science Foundation (Grant No. 2016M591505), the Natural Science Foundation of the Heilongjiang Province of China (Grant No. C200932), and the Heilongjiang Postdoctoral Fund (Grant No. LBH-Z14223). All authors have read the manuscript and have agreed to submit it in its current form for consideration for publication in the journal.

Compliance with Ethical Standards

All procedures used in the present study were approved by the Institutional Animal Care and Use Committee of Northeast Agricultural University.

Conflict of Interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Johri N, Jacquillet G, Unwin R (2010) Heavy metal poisoning: the effects of cadmium on the kidney. Biometals 23:783–792CrossRefPubMedGoogle Scholar
  2. 2.
    Marettova E, Maretta M, Legath J (2015) Toxic effects of cadmium on testis of birds and mammals: a review. Anim Reprod Sci 155:1–10CrossRefPubMedGoogle Scholar
  3. 3.
    Nookabkaew S, Rangkadilok N, Prachoom N, Satayavivad J (2016) Concentrations of trace elements in organic fertilizers and animal manures and feeds and cadmium contamination in herbal tea (Gynostemma pentaphyllum Makino. J Agric Food Chem 64:3119–3126CrossRefPubMedGoogle Scholar
  4. 4.
    Zhang F, Li Y, Yang M, Li W (2012) Content of heavy metals in animal feeds and manures from farms of different scales in Northeast China. Int J Environ Res Public Health 9:2658–2668CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Cang L, Wang YJ, Zhou DM, Dong YH (2004) Heavy metals pollution in poultry and livestock feeds and manures under intensive farming in Jiangsu Province, China. J Environ Sci (China) 16:371–374Google Scholar
  6. 6.
    Li YX, Xiong X, Lin CY, Zhang FS, Wei L, Wei H (2010) Cadmium in animal production and its potential hazard on Beijing and Fuxin farmlands. J Hazard Mater 177:475–480CrossRefPubMedGoogle Scholar
  7. 7.
    Fujiwara Y, Lee JY, Tokumoto M, Satoh M (2012) Cadmium renal toxicity via apoptotic pathways. Biol Pharm Bull 35:1892–1897CrossRefPubMedGoogle Scholar
  8. 8.
    Thijssen S, Maringwa J, Faes C, Lambrichts I, Van Kerkhove E (2007) Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology 229:145–156CrossRefPubMedGoogle Scholar
  9. 9.
    Jarup L (2002) Cadmium overload and toxicity. Nephrol Dial Transplant 17(Suppl 2):35–39CrossRefPubMedGoogle Scholar
  10. 10.
    Bridges CC, Zalups RK (2005) Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 204:274–308CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Thompson J, Hipwell E, Loo HV, Bannigan J (2005) Effects of cadmium on cell death and cell proliferation in chick embryos. Reprod Toxicol 20:539–548CrossRefPubMedGoogle Scholar
  12. 12.
    Muller L (1986) Consequences of cadmium toxicity in rat hepatocytes: mitochondrial dysfunction and lipid peroxidation. Toxicology 40:285–295CrossRefPubMedGoogle Scholar
  13. 13.
    Yao HD, Wu Q, Zhang ZW, Zhang JL, Li S, Huang JQ, Ren FZ, Xu SW, Wang XL, Lei XG (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of se-deficient chicks. J Nutr 143:613–619CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Sun L, Yu Y, Huang T, An P, Yu D, Yu Z, Li H, Sheng H, Cai L, Xue J, Jing M, Li Y, Lin X, Wang F (2012) Associations between ionomic profile and metabolic abnormalities in human population. PLoS One 7:e38845CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Swiergosz-Kowalewska R (2001) Cadmium distribution and toxicity in tissues of small rodents. Microsc Res Tech 55:208–222CrossRefPubMedGoogle Scholar
  16. 16.
    Al-Waeli A, Pappas AC, Zoidis E, Georgiou CA, Fegeros K, Zervas G (2012) The role of selenium in cadmium toxicity: interactions with essential and toxic elements. Br Poult Sci 53:817–827CrossRefPubMedGoogle Scholar
  17. 17.
    Jihen EH, Imed M, Fatima H, Abdelhamid K (2009) Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress. Ecotoxicol Environ Saf 72:1559–1564CrossRefGoogle Scholar
  18. 18.
    Messaoudi I, El HJ, Hammouda F, Said K, Kerkeni A (2009) Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. Biol Trace Elem Res 130:152–161CrossRefPubMedGoogle Scholar
  19. 19.
    Jihen EH, Imed M, Fatima H, Abdelhamid K (2008) Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem Toxicol 46:3522–3527CrossRefGoogle Scholar
  20. 20.
    Lopez-Alonso M, Miranda M, Castillo C, Hernandez J, Garcia-Vaquero M, Benedito JL (2007) Toxic and essential metals in liver, kidney and muscle of pigs at slaughter in Galicia, north-west Spain. Food Addit Contam 24:943–954CrossRefPubMedGoogle Scholar
  21. 21.
    Jemai H, Messaoudi I, Chaouch A, Kerkeni A (2007) Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. J Trace Elem Med Biol 21:269–273CrossRefPubMedGoogle Scholar
  22. 22.
    Hatfield DL, Tsuji PA, Carlson BA, Gladyshev VN (2014) Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem Sci 39:112–120CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    El-Boshy ME, Risha EF, Abdelhamid FM, Mubarak MS, Hadda TB (2015) Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats. J Trace Elem Med Biol 29:104–110CrossRefPubMedGoogle Scholar
  24. 24.
    Li JL, Gao R, Li S, Wang JT, Tang ZX, Xu SW (2010) Testicular toxicity induced by dietary cadmium in cocks and ameliorative effect by selenium. Biometals 23:695–705CrossRefPubMedGoogle Scholar
  25. 25.
    Newairy AA, El-Sharaky AS, Badreldeen MM, Eweda SM, Sheweita SA (2007) The hepatoprotective effects of selenium against cadmium toxicity in rats. Toxicology 242:23–30CrossRefPubMedGoogle Scholar
  26. 26.
    El-Sharaky AS, Newairy AA, Badreldeen MM, Eweda SM, Sheweita SA (2007) Protective role of selenium against renal toxicity induced by cadmium in rats. Toxicology 235:185–193CrossRefPubMedGoogle Scholar
  27. 27.
    Liu L, Yang B, Cheng Y, Lin H (2015) Ameliorative effects of selenium on cadmium-induced oxidative stress and endoplasmic reticulum stress in the chicken kidney. Biol Trace Elem Res 167:308–319CrossRefPubMedGoogle Scholar
  28. 28.
    Lazarus M, Orct T, Jurasoviae J, Blanusa M (2009) The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats. Biometals 22:973–983CrossRefPubMedGoogle Scholar
  29. 29.
    Liu LL, Li CM, Zhang ZW, Zhang JL, Yao HD, Xu SW (2014) Protective effects of selenium on cadmium-induced brain damage in chickens. Biol Trace Elem Res 158:176–185CrossRefPubMedGoogle Scholar
  30. 30.
    Pappas AC, Zoidis E, Georgiou CA, Demiris N, Surai PF, Fegeros K (2011) Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28:446–454CrossRefPubMedGoogle Scholar
  31. 31.
    Xu T, Gao X, Liu G (2016) The antagonistic effect of selenium on lead toxicity is related to the ion profile in chicken liver. Biol Trace Elem Res 169:365–373CrossRefPubMedGoogle Scholar
  32. 32.
    Jin X, Liu CP, Teng XH, Fu J (2016) Effects of dietary selenium against lead toxicity are related to the ion profile in chicken muscle. Biol Trace Elem Res. doi: 10.1007/s12011-015-0585-z Google Scholar
  33. 33.
    Zhang R, Wang L, Zhao J, Wang C, Bao J, Li J (2016) Effects of selenium and cadmium on ion profiles in the brains of chickens. Biol Trace Elem Res. doi: 10.1007/s12011-016-0693-4 Google Scholar
  34. 34.
    Nordberg GF, Jin T, Nordberg M (1994) Subcellular targets of cadmium nephrotoxicity: cadmium binding to renal membrane proteins in animals with or without protective metallothionein synthesis. Environ Health Perspect 102(Suppl 3):191–194CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Zwolak I, Zaporowska H (2012) Selenium interactions and toxicity: a review. Selenium interactions and toxicity. Cell Biol Toxicol 28:31–46CrossRefPubMedGoogle Scholar
  36. 36.
    Marettova E, Maretta M, Legath J, Kosutzka E (2012) The retention of cadmium and selenium influence in fowl and chickens of F1 generation. Biol Trace Elem Res 147:130–134CrossRefPubMedGoogle Scholar
  37. 37.
    Messaoudi I, Hammouda F, El HJ, Baati T, Said K, Kerkeni A (2010) Reversal of cadmium-induced oxidative stress in rat erythrocytes by selenium, zinc or their combination. Exp Toxicol Pathol 62:281–288CrossRefPubMedGoogle Scholar
  38. 38.
    Benderli CY, Sozen S, Ozturk YS (2011) Trace elements and heavy metals in hair of stage III breast cancer patients. Biol Trace Elem Res 144:360–379CrossRefGoogle Scholar
  39. 39.
    Noel L, Guerin T, Kolf-Clauw M (2004) Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health. Food Chem Toxicol 42:1203–1210CrossRefPubMedGoogle Scholar
  40. 40.
    Kobayashi K, Himeno S, Satoh M, Kuroda J, Shibata N, Seko Y, Hasegawa T (2006) Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms. Toxicology 228:162–170CrossRefPubMedGoogle Scholar
  41. 41.
    Mirfendereski E, Jahanian R (2015) Effects of dietary organic chromium and vitamin C supplementation on performance, immune responses, blood metabolites, and stress status of laying hens subjected to high stocking density. Poult Sci 94:281–288CrossRefPubMedGoogle Scholar
  42. 42.
    Santamaria AB, Sulsky SI (2010) Risk assessment of an essential element: manganese. J Toxicol Environ Health A 73:128–155CrossRefPubMedGoogle Scholar
  43. 43.
    Anke M, Seifert M, Holzinger S, Muller R, Schafer U (2007) The biological and toxicological importance of molybdenum in the environment and in the nutrition of plants, animals and man. Part 2: molybdenum in animals and man. Acta Biol Hung 58:325–333CrossRefPubMedGoogle Scholar
  44. 44.
    Fubini B, Hubbard A (2003) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 34:1507–1516CrossRefPubMedGoogle Scholar
  45. 45.
    Cao H, Su R, Hu G, Li C, Guo J, Pan J, Tang Z (2016) In vivo effects of high dietary copper levels on hepatocellular mitochondrial respiration and electron transport chain enzymes in broilers. Br Poult Sci 57:63–70CrossRefPubMedGoogle Scholar
  46. 46.
    Musik I, Kocot J, Kielczykowska M (2015) Effect of sodium selenite on chosen anti- and pro-oxidative parameters in rats treated with lithium: a pilot study. Pharmacol Rep 67:446–450CrossRefPubMedGoogle Scholar
  47. 47.
    Losler S, Schlief S, Kneifel C, Thiel E, Schrezenmeier H, Rojewski MT (2009) Antimony-trioxide- and arsenic-trioxide-induced apoptosis in myelogenic and lymphatic cell lines, recruitment of caspases, and loss of mitochondrial membrane potential are enhanced by modulators of the cellular glutathione redox system. Ann Hematol 88:1047–1058CrossRefPubMedGoogle Scholar
  48. 48.
    Zoidis E, Pappas AC, Georgiou CA, Komaitis E, Feggeros K (2010) Selenium affects the expression of GPx4 and catalase in the liver of chicken. Comp Biochem Physiol B Biochem Mol Biol 155:294–300CrossRefPubMedGoogle Scholar
  49. 49.
    Lopez AM, Prieto MF, Miranda M, Castillo C, Hernandez J, Luis BJ (2004) Interactions between toxic (As, Cd, Hg and Pb) and nutritional essential (Ca, Co, Cr, Cu, Fe, Mn, Mo, Ni, Se, Zn) elements in the tissues of cattle from NW Spain. Biometals 17:389–397CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinPeople’s Republic of China
  2. 2.College of Life ScienceNortheast Agricultural UniversityHarbinPeople’s Republic of China

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