Pharmacotherapy and imaging are two critical facets of cancer therapy. Carbon nanotubes and their modified species such as magnetic or gold nanoparticle conjugated ones they have been introduced as good candidates for both purposes. Gold nanoparticles enhance effects of X-rays during radiotherapy. Nanomaterial-mediated radiofrequency (RF) hyperthermia refers to using RF to heat tumors treated with nanomaterials for cancer therapy. The combination of hyperthermia and radiotherapy, synergistically, causes a significant reduction in X-ray doses. The present study was conducted to investigate the ability and efficiency of the multi-walled carbon nanotubes functionalized with magnetic Fe3O4 and gold nanoparticles (mf-MWCNT/AuNPs) for imaging and cancer therapy. The mf-MWCNT/AuNPs were utilized for imaging approaches such as ultrasounds, CT scan, and MRI. They were also examined in thermotherapy and radiotherapy. The MCF-7 cell line was used as an in vitro model to study thermotherapy and radiotherapy. The mf-MWCNT/AuNPs are beneficial as a contrast agent in imaging by ultrasounds, CT scan, and MRI. They are also radio waves and X-rays absorbent and enhance the efficiency of thermotherapy and radiotherapy in the elimination of cancer cells. The valuable properties of mf-MWCNT/AuNPs in radio- and thermotherapies and imaging strategies make them a good candidate as a multimodal tool in cancer therapy.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Liu, X., Chen, H.-J., Chen, X., Alfadhl, Y., Yu, J., & Wen, D. (2015). Radiofrequency heating of nanomaterials for cancer treatment: progress, controversies, and future development. Applied Physics Reviews, 2, 011103.
Khan, S. A., Kanchanapally, R., Fan, Z., Beqa, L., Singh, A. K., Senapati, D., & Ray, P. C. (2012). A gold nanocage–CNT hybrid for targeted imaging and photothermal destruction of cancer cells. Chemical Communications, 48(53), 6711–6713.
Tong, S., Quinto, C. A., Zhang, L., Mohindra, P., & Bao, G. (2017). Size-dependent heating of magnetic iron oxide nanoparticles. ACS Nano, 11, 6808–6816.
Corot, C., Robert, P., Idée, J.-M., & Port, M. (2006). Recent advances in iron oxide nanocrystal technology for medical imaging. Advanced Drug Delivery Reviews, 58, 1471–1504.
Ito, A., Shinkai, M., Honda, H., & Kobayashi, T. (2005). Medical application of functionalized magnetic nanoparticles. Journal of Bioscience and Bioengineering, 100(1), 1–11.
Piraner, D. I., Farhadi, A., Davis, H. C., Wu, D., Maresca, D., Szablowski, J. O., & Shapiro, M. G. (2017). Going deeper: biomolecular tools for acoustic and magnetic imaging and control of cellular function. Biochemistry, 56(39), 5202–5209.
Delogu, L. G., Vidili, G., Venturelli, E., Ménard-Moyon, C., Zoroddu, M. A., Pilo, G., Nicolussi, P., Ligios, C., Bedognetti, D., Sgarrella, F., Manetti, R., & Bianco, A. (2012). Functionalized multiwalled carbon nanotubes as ultrasound contrast agents. Proceedings of the National Academy of Sciences, 109, 16612–16617.
Liu, Y., Muir, B. W., Waddington, L. J., Hinton, T. M., Moffat, B. A., Hao, X., Qiu, J., & Hughes, T. C. (2015). Colloidally stabilized magnetic carbon nanotubes providing MRI contrast in mouse liver tumors. Biomacromolecules, 16, 790–797.
Meir, R., Betzer, O., Motiei, M., Kronfeld, N., Brodie, C., & Popovtzer, R. (2017). Design principles for noninvasive, longitudinal and quantitative cell tracking with nanoparticle-based CT imaging. Nanomedicine: Nanotechnology, Biology and Medicine, 13, 421–429.
Hainfeld, J. F., Lin, L., Slatkin, D. N., Dilmanian, F. A., Vadas, T. M., & Smilowitz, H. M. (2014). Gold nanoparticle hyperthermia reduces radiotherapy dose. Nanomedicine: Nanotechnology, Biology and Medicine, 10, 1609–1617.
Collins, C., McCoy, R., Ackerson, B., Collins, G., & Ackerson, C. (2014). Radiofrequency heating pathways for gold nanoparticles. Nanoscale, 6(15), 8459–8472.
Nordebo, S., Dalarsson, M., Ivanenko, Y., Sjöberg, D., & Bayford, R. (2017). On the physical limitations for radio frequency absorption in gold nanoparticle suspensions. Journal of Physics D: Applied Physics, 50, 155401.
Boutry, S., Muller, R., & Laurent, S. (2018). In iron oxide nanoparticles for biomedical applications (pp. 135–164). Elsevier.
Kim, J., Chhour, P., Hsu, J., Litt, H. I., Ferrari, V. A., Popovtzer, R., & Cormode, D. P. (2017). Use of nanoparticle contrast agents for cell tracking with computed tomography. Bioconjugate Chemistry, 28, 1581–1597.
Lee, N., Choi, S. H., & Hyeon, T. (2013). Nano-sized CT contrast agents. Advanced Materials, 25, 2641–2660.
Kaboudin, B., Saghatchi, F., & Kazemi, F. (2019). Synthesis and characterization of magnetic carbon nanotubes functionalized with pyridine groups-supported gold nanoparticles and their application in catalytic oxidation of alcohols in water. Journal of Organometallic Chemistry, 882, 64–69.
Kaboudin, B., Saghatchi, F., Kazemi, F., & Akbari-Birgani, S. (2018). A novel magnetic carbon nanotubes functionalized with pyridine groups: synthesis, characterization and their application as an efficient carrier for plasmid DNA and aptamer. ChemistrySelect, 3, 6743–6749.
Cai, J., Shapiro, E. M., & Hamilton, A. D. (2009). Self-assembling DNA quadruplex conjugated to MRI contrast agents. Bioconjugate Chemistry, 20(2), 205–208.
Li, R., Wu, R. a., Zhao, L., Qin, H., Wu, J., Zhang, J., Bao, R., & Zou, H. (2014). In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging. Nanotechnology, 25, 495102.
Cheheltani, R., Ezzibdeh, R. M., Chhour, P., Pulaparthi, K., Kim, J., Jurcova, M., Hsu, J. C., Blundell, C., Litt, H. I., & Ferrari, V. A. (2016). Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging. Biomaterials, 102, 87–97.
Wang, N., Feng, Y., Zeng, L., Zhao, Z., & Chen, T. (2015). Functionalized multiwalled carbon nanotubes as carriers of ruthenium complexes to antagonize cancer multidrug resistance and radio resistance. ACS Applied Materials & Interfaces, 7(27), 14933–14945.
Bianco, A., Kostarelos, K., & Prato, M. (2005). Applications of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology, 9(6), 674–679.
Mohseni-Dargah, M., Akbari-Birgani, S., Madadi, Z., Saghatchi, F., & Kaboudin, B. (2019). Carbon nanotube-delivered iC9 suicide gene therapy for killing breast cancer cells in vitro. Nanomedicine.
The authors gratefully acknowledge the Institute for Advanced Studies in Basic Sciences, Zanjan, Iran, for support and funding. They also thank Mehraneh charity for providing them with an ONCOR Digital Medical Linear Accelerator siemens (6 MV X-ray radiation) for radiotherapy and hyperthermia system Celsius 42 for thermotherapy.
This work was funded by the Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran.
Conflict of Interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Saghatchi, F., Mohseni-Dargah, M., Akbari-Birgani, S. et al. Cancer Therapy and Imaging Through Functionalized Carbon Nanotubes Decorated with Magnetite and Gold Nanoparticles as a Multimodal Tool. Appl Biochem Biotechnol 191, 1280–1293 (2020). https://doi.org/10.1007/s12010-020-03280-3
- Cancer therapy
- Multi-walled carbon nanotube
- Gold nanoparticle