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Effect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients

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Abstract

This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females. All the participants signed the informed consent form and answered the public health questionnaire. Samples of buccal epithelial and peripheral blood cells were collected and analyzed through micronucleus and comet assays. The cells were evaluated for apoptosis and DNA damage. Results showed the association of patients’ family history with an increase in toxicogenetic damage before and during cancer therapy. On the other hand, patients with late-onset cancer also presented genetic instability before and during therapy, along with those who did not take sufficient vegetables and alternative therapies. A positive correlation was observed between the genetic instability and alternative therapies, while inverse correlation was recorded with the vegetable consumption. Results clearly explain that the nutritional aspects and alternative therapies influence the genetic instability before and during cancer therapies especially in radiotherapy treated patients. Our data could be used for the monitoring therapies and management of breast cancer patients.

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Acknowledgements

The authors gratefully acknowledge the research facilities provided by the Federal University at Piauí, Brazil, and King Fahd Medical Research Center (KFMRC), King Abdulaziz University, Jeddah, Saudi Arabia.

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Authors and Affiliations

  1. Laboratory of Genetic Toxicology, PPGBioSaúde and PPGGTA, Lutheran University of Brazil (ULBRA), Av. Farroupilha 8001, Prédio 22, Sala 22 (4° Andar), Canoas, RS, 92425-900, Brazil

    Márcia Fernanda Correia Jardim Paz & Juliana da Silva

  2. Northeast Biotechnology Network (RENORBIO), Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil

    Márcia Fernanda Correia Jardim Paz, Antônio Luiz Gomes Júnior, Marcus Vinícius Oliveira Barros de Alencar, Keylla da Conceição Machado, Kátia da Conceição Machado, Felipe Cavalcanti Carneiro da Silva, André Luiz Pinho Sobral, João Marcelo de Castro e Sousa, Germano Pinho de Moraes & Ana Amélia de Carvalho Melo-Cavalcante

  3. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Shams Tabrez, Nasimudeen R. Jabir & Mohammad Zubair Alam

  4. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam

    Muhammad Torequl Islam

  5. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam

    Muhammad Torequl Islam

  6. Center of Excellence in Environmental Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Mohammad Oves

  7. Department of Medical Biology, University of Quebec, Trois Riveres, Canada

    Muhammad Nadeem Asghar

  8. Gaco Pharmaceuticals and Research Laboratory, Dhaka, 1000, Bangladesh

    Eunüs S. Ali

  9. College of Medicine and Public Health, Flinders University, Bedford Park, 5042, Australia

    Eunüs S. Ali

  10. Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar, 470003, India

    Siddhartha Kumar Mishra

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  1. Márcia Fernanda Correia Jardim Paz
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Contributions

Márcia Fernanda Correia Jardim Paz: Performed the experimental work

Antônio Luiz Gomes Júnior: Performed the experimental work

Marcus Vinícius Oliveira Barros de Alencar: Performed the experimental work

Shams Tabrez: Conceived, guided, and proofread the article

Muhammad Torequl Islam: Performed the experimental work and wrote the first draft of the manuscript

Nasimudeen R Jabir: Wrote the first draft of the manuscript and proofread it

Mohammad Oves: Guided the work and helped troubleshoot different experiments

Mohammad Zubair Alam: Guided the work and helped troubleshoot different experiments

Muhammad Nadeem Asghar: Proofread the manuscript and was also involved in the revision

Eunüs S. Ali: Was involved in the statistical analysis

Keylla da Conceição Machado: Wrote the first draft of the manuscript and was also involved in the revision

Kátia da Conceição Machado: Wrote the first draft of the manuscript

Felipe Cavalcanti Carneiro da Silva: Supervised the work and was also involved in the statistical analysis

André Luiz Pinho Sobral: Sample collection, questionnaire filling, and sample handling

João Marcelo de Castro e Sousa: Sample collection, questionnaire filling, and sample handling

Germano Pinho de Moraes: Supervised the work and was also involved in the statistical analysis

Siddhartha Kumar Mishra: Proofread the manuscript

Ana Amélia de Carvalho Melo Cavalcante: Guided the work and wrote the first draft of the manuscript

Juliana da Silva: Proofread the manuscript

Corresponding authors

Correspondence to Shams Tabrez or Muhammad Torequl Islam.

Ethics declarations

This study was performed in compliance with the Helsinki Declaration and was approved by the Ethics Committee of the Centro de Universitário UNINOVAFAPI 0406.0.043.000-11 (approval number: 0406.0.043.000-11).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Paz, M.F.C.J., Gomes Júnior, A.L., de Alencar, M.V.O.B. et al. Effect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients. Appl Biochem Biotechnol 188, 282–296 (2019). https://doi.org/10.1007/s12010-018-2918-9

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