Applied Biochemistry and Biotechnology

, Volume 186, Issue 2, pp 443–458 | Cite as

Nanofibrous Tubular Membrane for Blood Hemodialysis

  • Farideh Mohammadi
  • Afsaneh Valipouri
  • Dariush Semnani
  • Fereshteh Alsahebfosoul


As the most important components of a hemodialysis device, nanofibrous membranes enjoy high interconnected porosity and specific surface area as well as excellect permeability. In this study, a tubular nanofibrous membrane of polysulfone nanofibers was produced via electrospinning method to remove urea and creatinine from urine and blood serums of dialysis patients. Nanofibrous membranes were electrospun at a concentration of 11.5 wt% of polysulfone (PS) and dimethylformamide (DMF)/tetrahydrofuran (THF) with a ratio of 70/30. The effects of the rotational speed of collectors, electrospinning duration, and inner diameter of the tubular nanofibrous membrane on the urea and creatinine removal efficiency of the tubular membrane were investigated through the hemodialysis simulation experiments. It was found that the tubular membrane with an inner diameter of 3 mm elecrospun at shorter duration with lower collecting speed had the highest urea and creatinine removal efficiency. The hemodialysis simulation experiment showed that the urea and creatinine removal efficiency of the tubular membrane with a diameter of 3 mm were 90.4 and 100%, respectively. Also, three patients’ blood serums were tested with the nanofibrous membrane. The results showed that the creatinine and urea removal rates were 93.2 and 90.3%, respectively.


Nanofibrous membrane Blood hemodialysis Urea and creatinine removal 



The authors received no financial support for the research, authorship, and/or publication of this article.

Compliance with Ethical Standards

Conflict of Interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Textile EngineeringIsfahan University of TechnologyIsfahanIran
  2. 2.Department of Immunology, School of MedicineIsfahan University of Medical SciencesIsfahanIran

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