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A Novel Approach in Treatment of Tuberculosis by Targeting Drugs to Infected Macrophages Using Biodegradable Nanoparticles

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Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis is now causing death of more than 10 million people. Because of the development of drug-resistant TB, drug delivery to the infected site through nanoparticle had been studied for long time. Nanoparticles indicate different sorts of association with the natural particles of the body. Nanoparticles can be used as controlled or specific drug delivery system. It can be through temporal controlled or can be distribution controlled. Glucose polymer-based nanoparticles might play an important role as drug delivery system in case of targeted drug delivery in the infected site of the body or in infected macrophages, as they are biodegradable so there should not be any side effects of these particles in the body and also they show very slow immune response. CD4, Beta 1, TGFb-1, IL-2, IL-13 SEC14L1, GUSB, BPI, and CCR7 are major biomarkers secreted after infection of this bacterium by the macrophages which can be used for targeted drug delivery in infected macrophages. As these markers can be used for delivery of drugs at destined position, they can be very beneficial in reducing toxicities of antituberculer drugs to the other uninfected sites and in operating only the infected macrophages.

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Abbreviations

TB:

Tuberculosis

Mtb :

Mycobacterium tuberculosis

INH:

Isoniazid

RIF:

Rifampicin

PZA:

Pyrazinamide

AMs:

Alveolar macrophages

MIC:

Minimal inhibitory concentration

IFN-γ:

Interferon gamma

IL-2:

Interleukin- 2

CD4:

Cluster of differentiation 4

TGFb-1:

Transforming growth factor beta 1

IL-2:

Interleukin

IL-13:

Interleukin

SEC14L1:

Sec14- like lipid binding 1

GUSB:

Glucuronidase beta

BPI:

Bactericidal/permeability-increasing protein

CCR7:

C-C chemokine receptor type 7

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Funding

The authors acknowledge financial support from the Department of Science and Technology-SERB, Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, under the research project GAP0145.

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  1. CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Mall Road, Delhi, 110007, India

    Shivangi & Laxman S. Meena

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Correspondence to Laxman S. Meena.

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Shivangi, Meena, L.S. A Novel Approach in Treatment of Tuberculosis by Targeting Drugs to Infected Macrophages Using Biodegradable Nanoparticles. Appl Biochem Biotechnol 185, 815–821 (2018). https://doi.org/10.1007/s12010-018-2695-5

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