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Evaluation of Octyl-β-D-Glucopyranoside (OGP) for Cytotoxic, Hemolytic, Thrombolytic, and Antibacterial Activity

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Abstract

The current study indicates that octyl-β-D-glucopyranoside (OGP) as a detergent which has the ability to make the lipid layer stiff. OGP was subjected for toxicity studies and in vitro cytotoxicty assays on cancerous HeLa and non-cancerous myoblasts H9c2 cell lines. Test against aquatic organisms were carried out in Artemia salina and LC50 values were calculated. Hemolytic activity tested for blood bio-compalibity showed hemolysis rate of 10–16%, followed by thrombolytic activity to burst the clots in blood. Also, the samples showed good lysis when compared to the standard streptokinase. Furthermore, α-amylase activity has been carried out to check the inhibition of α-amylase by the OGP. Finally, antibacterial activity has been tested against four different pathogens and their MIC values have been calculated.

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Authors and Affiliations

  1. Department of Biotechnology, School of Biosciences and Technology, VIT University, Vellore, Tamilnadu, 632014, India

    Murugesan Dinesh, Subramanyam Deepika, Rajendran HarishKumar & Chinnadurai Immanuel Selvaraj

  2. Chemistry of Heterocycles and Natural Product Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamilnadu, 632014, India

    Selvaraj Mohana Roopan

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  1. Murugesan Dinesh
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  2. Subramanyam Deepika
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  4. Chinnadurai Immanuel Selvaraj
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Correspondence to Chinnadurai Immanuel Selvaraj or Selvaraj Mohana Roopan.

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Dinesh, M., Deepika, S., HarishKumar, R. et al. Evaluation of Octyl-β-D-Glucopyranoside (OGP) for Cytotoxic, Hemolytic, Thrombolytic, and Antibacterial Activity. Appl Biochem Biotechnol 185, 450–463 (2018). https://doi.org/10.1007/s12010-017-2661-7

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