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Electrospun Polyvinyl Alcohol/ Pluronic F127 Blended Nanofibers Containing Titanium Dioxide for Antibacterial Wound Dressing

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Abstract

In this study, an antibacterial electrospun nanofibers for wound dressing application was successfully prepared from polyvinyl alcohol (PVA), Pluronic F127 (Plur), polyethyleneimine (PEI) blend solution with titanium dioxide nanoparticles (TiO2 NPs). PVA–Plur–PEI nanofibers containing various ratios of TiO2 NPs were obtained. The formation and presence of TiO2 in the PVA–Plu–PEI/ TiO2 composite was confirmed by X-ray diffraction (XRD). Transmission electron microscopy (TEM), Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), mechanical measurement, and antibacterial activity were undertaken in order to characterize the PVA–Plur–PEI/TiO2 nanofiber morphology and properties. The PVA–Plu–PEI nanofibers had a mean diameter of 220 nm, and PVA–Plur–PEI/TiO2 nanofibers had 255 nm. Moreover, the antimicrobial properties of the composite were studied by zone inhibition against Gram-negative bacteria, and the result indicates high antibacterial activity. Results of this antibacterial testing suggest that PVA–Plur–PEI/TiO2 nanofiber may be effective in topical antibacterial treatment in wound care; thus, they are very promising in the application of wound dressings.

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Acknowledgments

This work was supported by postdoc Programs Foundation of Ministry of Education of China Grant No is (2015 M57145)

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Authors and Affiliations

  1. Colleges of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    M. R. El-Aassar & Xiumei Mo

  2. Polymer Materials Research Department, Advanced Technology and New Material Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt

    M. R. El-Aassar & G. F. El fawal

  3. Biopharmaceutical Product Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Researches and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria, 21934, Egypt

    Nehal M. El-Deeb

  4. Electronic Materials Researches Department, Institute of Advanced Technology and New Material Research Institute, City of Scientific Researches and technological applications (SRTA-City), New Borg El-Arab City, Alexandria, 21934, Egypt

    H. Shokry Hassan

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  1. M. R. El-Aassar
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  2. G. F. El fawal
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Correspondence to M. R. El-Aassar or G. F. El fawal.

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El-Aassar, M.R., El fawal, G.F., El-Deeb, N.M. et al. Electrospun Polyvinyl Alcohol/ Pluronic F127 Blended Nanofibers Containing Titanium Dioxide for Antibacterial Wound Dressing. Appl Biochem Biotechnol 178, 1488–1502 (2016). https://doi.org/10.1007/s12010-015-1962-y

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