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The Chemical Diversity of the Ascomycete Fungus Paecilomyces variotii

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Abstract

Paecilomyces variotii isolated from a broad range of habitats drives the diversification of new high-value-added secondary metabolites that could potentially play an important role in human and animal health. These metabolites include the anhydride metabolite of the nonadride family, as well as the following compounds: naphthopyranone metabolites, sphingofungins, eicosenoic acids, new branched fatty acids, ascofuranone, polyketides, an anacardic acid analogue, straight-chain peptides, and volatile compounds. These natural products show that P. variotii can provide leading compounds for new drug discoveries, which may include herbicide agents, some of which are important in the agrochemical market. Finally, this review outlines recent developments, trends, and prospects for the chemistry of this ascomycete.

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Conflict of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Biochemistry, Federal University of Pernambuco - UFPE, Recife, Pernambuco, 50740-465, Brazil

    Roberto Mioso

  2. Department of Chemistry, University of Las Palmas de Gran Canaria - ULPGC, 35017, Las Palmas de Gran Canaria, Spain

    Francisco Javier Toledo Marante

  3. Department of Biology, University of Las Palmas de Gran Canaria - ULPGC, 35017, Las Palmas de Gran Canaria, Spain

    Irma Herrera Bravo de Laguna

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  1. Roberto Mioso
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  2. Francisco Javier Toledo Marante
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  3. Irma Herrera Bravo de Laguna
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Correspondence to Irma Herrera Bravo de Laguna.

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Highlights

• Paecilomyces variotii fungus efficiently produces secondary metabolites.

• Bioactive compounds produced by P. variotii are reviewed.

• Research focused on high-value products obtained from P. variotii fungus.

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Mioso, R., Toledo Marante, F.J. & Herrera Bravo de Laguna, I. The Chemical Diversity of the Ascomycete Fungus Paecilomyces variotii . Appl Biochem Biotechnol 177, 781–791 (2015). https://doi.org/10.1007/s12010-015-1783-z

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