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Evidence of a New Intermediate Compound of the Chitin Biogenesis Found in a Marine-Derived Fungus

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Abstract

The chemical screening of the biomass of a new marine-derived strain of Penicillium roqueforti, produced by liquid-state fermentation, led to the identification of several volatile and nonvolatile compounds. As a result of previous studies, we have isolated and characterized a new molecule. The chemical structure of 2-deoxy-2-phosphamino-α-D-glucopyranose isolated was elucidated on the basis of 1D and 2D NMR studies together with other instrumental techniques. As a result of this discovery, a biogenetic route has been proposed to explain its formation as an intermediary component of the chitin biosynthesis.

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Acknowledgments

The authors would like to thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior agency (CAPES, Brazil) for the Ph.D. fellowship and the European Commission for a Marie Curie Training Site Fellowship, both granted to R.M. Grateful acknowledgement is made of the financial support given to the project SI-697 (ULPAPD-08/01-5) by the Canary government (Agencia Canaria de Investigación, Innovación y Sociedad de la Información, ACIISI) and the Instituto Canario de Investigación del Cáncer (ICIC). This work was co-funded by research grants from the Spanish MICINN, Ref. No. BIO2011-29233-C02-02 and Agencia Canaria de Investigación, Innovación y Sociedad de la Información, Ref. No. PIL2071001.

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Authors and Affiliations

  1. Chemistry Department, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35017, Spain

    Francisco Javier Toledo Marante & Roberto Mioso

  2. Biology Department, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35017, Spain

    Irma Herrera Bravo de Laguna

  3. Biochemistry and Molecular Biology Department, Instituto de Tecnología Biomédica, Universidad de La Laguna, San Cristóbal de La Laguna, Spain

    Néstor Vicente Torres

Authors
  1. Francisco Javier Toledo Marante
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  2. Irma Herrera Bravo de Laguna
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  3. Néstor Vicente Torres
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  4. Roberto Mioso
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Corresponding author

Correspondence to Irma Herrera Bravo de Laguna.

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Toledo Marante, F.J., Herrera Bravo de Laguna, I., Torres, N.V. et al. Evidence of a New Intermediate Compound of the Chitin Biogenesis Found in a Marine-Derived Fungus. Appl Biochem Biotechnol 174, 2426–2434 (2014). https://doi.org/10.1007/s12010-014-1180-z

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  • DOI: https://doi.org/10.1007/s12010-014-1180-z

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