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Insulin Resistance Associated Genes and miRNAs

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Abstract

Type 2 diabetes mellitus is the result of resistance to insulin function along with inadequate insulin secretion, leading to a number of dysfunctions characterized by hyperglycemia, and it is associated with microvascular, macrovascular, and neuropathic complications. There is compelling evidence that the decline in both insulin sensitivity and insulin secretion has a genetic component. In addition, increasing evidence suggests that microRNAs (miRNAs) as key regulators of gene expression play significant roles in insulin production, secretion, and function that regulate the function of insulin-target tissues. The current review demonstrates the candidate genes and the related miRNAs involved in molecular pathogenesis of insulin resistance in type 2 diabetes mellitus. In doing so, it provides an opportunity for more focused investigations that may identify the genes and miRNAs with a role in the pathogenesis of type 2 diabetes mellitus and its treatment.

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Authors and Affiliations

  1. Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

    Maryam Honardoost & Mohammad reza Sarookhani

  2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

    Maryam Honardoost & Mohammad reza Sarookhani

  3. Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran

    Maryam Honardoost & Masoud Soleimani

  4. Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran

    Ehsan Arefian

  5. Department of Hematology, School of Medical Sciences, Tarbiat Modares University, P.O.Box 14115-331, Tehran, Iran

    Masoud Soleimani

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  1. Maryam Honardoost
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  2. Mohammad reza Sarookhani
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Honardoost, M., reza Sarookhani, M., Arefian, E. et al. Insulin Resistance Associated Genes and miRNAs. Appl Biochem Biotechnol 174, 63–80 (2014). https://doi.org/10.1007/s12010-014-1014-z

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